DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp8

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_071557.1	Gene:	Mmp8 / 63849	RGDID:	631408	Length:	466	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	174/461 - (37%)
Similarity:	238/461 - (51%)	Gaps:	73/461 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AEIYLSQFGYLPA----SARNPASSGLHDQRTWVS-AIEEFQSFAGLNITGELDAETMKLMSLPR 92
            ||.||.:|.:||:    ||||         .|.:: .::|.|.|.||..||:.||.|:::|..||
  Rat    36 AENYLRKFYHLPSNQFRSARN---------ATMIAEKLKEMQRFFGLPETGKPDAATIEIMEKPR 91

  Fly    93 CGVRDRVGTGDSRSKRYAL-QGS-RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLT 155
            |||.|   :||     :.| .|| :|...||||:|..:..::.:.:|..||.:||.:||..:.||
  Rat    92 CGVPD---SGD-----FLLTPGSPKWTHTNLTYRIINHTPQMSKAEVKTEIEKAFKIWSVPSTLT 148

  Fly   156 FTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VFGGDAHFDDAELWTIGSPRGTNL 218
            ||....|...|.|.||..:|||...|||..|.|||||.|  ..|||||||..|.||..| :..||
  Rat   149 FTETLEGEADINIAFVSRDHGDNSPFDGPNGILAHAFQPGRGIGGDAHFDSEETWTQDS-KNYNL 212

  Fly   219 FQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLDEDDKAAIQSLYGRKTNQLRPTNVYPA 282
            |.|||||||||||||||....|||.|.|...|| .:.|.:||...||::||...|.::||.
  Rat   213 FLVAAHEFGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPVQPTG---- 273

  Fly   283 TTQRPYSP----PKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQL---- 339
                |.:|    |.:..|.:           .:.:||.|.|| |||:       ...:|||
  Rat   274 ----PSTPTACDPHLRFDAA-----------TTLRGEIYFFK-DKYF-------WRRHPQLRTVD 315

  Fly   340 ---ISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHLDA 399
               ||..||.||..:.||: .:.....:.|||.|||......:...||::||. ||......:||
  Rat   316 LNFISLFWPFLPNGLQAAYEDFDRDLVFLFKGRQYWALSAYDLQQGYPRDISNYGFPRSVQAIDA 380

  Fly   400 AMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISN-WEGVPNNLDAALKYTNGYTYFFKGD 463
            |:.:  |||.|||..::.||:|..:| .:...||..|:: :.|:...:||..: .:.:..||.|.
  Rat   381 AVSY--NGKTYFFVNNQCWRYDNQRR-SMDPGYPTSIASVFPGINCRIDAVFQ-QDSFFLFFSGP 441

  Fly   464 KYYRFH 469
            :|:.|:
  Rat   442 QYFAFN 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	22/59 (37%)
		Peptidase_M10	115..268	CDD:278824	76/155 (49%)
		ZnMc_MMP	115..268	CDD:239805	76/155 (49%)
		HX	298..493	CDD:238046	55/182 (30%)
Mmp8	NP_071557.1	PG_binding_1	32..87	CDD:279773	22/59 (37%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/9 (67%)
		Peptidase_M10	108..263	CDD:278824	76/155 (49%)
		ZnMc_MMP	108..263	CDD:239805	76/155 (49%)
		HX	277..465	CDD:238046	58/194 (30%)
		Hemopexin 1	277..326		18/67 (27%)
		Hemopexin 2	327..373		15/45 (33%)
		Hemopexin 3	375..421		16/48 (33%)
		Hemopexin 4	422..465		7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850