DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp14

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001025559.1	Gene:	mmp14 / 594950	XenbaseID:	XB-GENE-485643	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	549	Identity:	202/549 - (36%)
Similarity:	292/549 - (53%)	Gaps:	61/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MAAAQSAPVSTTTQAEIYLSQFGYLPA------SARNPASSGLHDQRTWVSAIEEFQSFAGLNIT 77
            :.::.||..|    .|.:|.|:||||.      :.|:|.|..        :||...|.|.||.:|
Frog    16 VCSSSSAKFS----PEAWLQQYGYLPPGDLRTHTLRSPQSMN--------AAISAMQKFYGLKVT 68

  Fly    78 GELDAETMKLMSLPRCGVRDRVGT---GDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDA 139
            |..|:||.:.|..|||||.|:.|.   .:.|.||||:||.:|:.|::|:.|..|..::.......
Frog    69 GSFDSETERAMKRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHKDITFCIQNYTPKIGEYSTYE 133

  Fly   140 EIGRAFAVWSEDTDLTFTR------KTSGPVHIEIK--FVESEHGDGDAFDGQGGTLAHAFF--P 194
            .|.|||.||...|.|.|..      |.....|.:|.  |.|..|||...|||:||.||||:|  |
Frog   134 AIRRAFKVWESVTPLRFREVRYVDIKDGYTKHADIMLFFAEGFHGDSTPFDGEGGFLAHAYFPGP 198

  Fly   195 VFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-FKLD 256
            ..|||.|||.||.||..:.  .|.:||.||.||.||:|||.||:..||:|||||:..:.. |:|.
Frog   199 GIGGDTHFDSAEPWTARNDDLDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTQNFQLP 263

  Fly   257 EDDKAAIQSLYGRK------TNQLRPTNV-YPATTQRPYSPPKVP----LDDSICKDSKVDTLFN 310
            :||:..||.|||..      |...|||.. .|..||||...|..|    ....||: ...||: .
Frog   264 DDDRRGIQQLYGPNHGEGLPTRAPRPTRAPRPTQTQRPDDTPHDPNPPTYGPDICQ-GNFDTI-A 326

  Fly   311 SAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQG 375
            ..:||.:.||...::::....|.:|||..|.:.|.|||.:|::|:..|:||..||||.::|.:..
Frog   327 MLRGEMFVFKERWFWRVRHKRVMDGYPMPIGQFWRGLPSSINSAYERKDGKFVFFKGDKHWVFDE 391

  Fly   376 RQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW 439
            ..::..|||.:.|...|:| |.:|||:.|..|||.|||:|:|::||:...| .|...||||::.|
Frog   392 AILEPGYPKTLKELGRGLPSDRIDAALYWMPNGKTYFFRGTKYYRFNEEMR-AVDPDYPKPVNVW 455

  Fly   440 EGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNI 503
            ||:|:::..|...::| :|||:||:||::|::.....:|.   :|:.....|.||        :.
Frog   456 EGIPDSIKGAFMGSDGAFTYFYKGNKYWKFNNQLLKTESG---YPKSVLVDWMGC--------ST 509

  Fly   504 VEGSDNEFEQHSMIPHADDGNGDDFDAAV 532
            ....|::.::..:|...|:.:|....||:
Frog   510 ARQPDDDVDREVVIIEVDEASGGVSAAAI 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	21/61 (34%)
		Peptidase_M10	115..268	CDD:278824	71/165 (43%)
		ZnMc_MMP	115..268	CDD:239805	71/165 (43%)
		HX	298..493	CDD:238046	71/196 (36%)
mmp14	NP_001025559.1	PG_binding_1	27..79	CDD:366659	21/59 (36%)
		Peptidase_M10	109..275	CDD:334067	71/165 (43%)
		HX	315..507	CDD:238046	71/197 (36%)
		DUF3377	513..578	CDD:371766	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12189
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21040
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2436
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47536
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090