DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp1 and mmp3

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001025502.1	Gene:	mmp3 / 594917	XenbaseID:	XB-GENE-5932509	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	166/480 - (34%)
Similarity:	236/480 - (49%)	Gaps:	65/480 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVG 100
            ||..| |...:|....:|.:.::      |:..|.|.||.:||::|:.||.::..|||||.|
Frog    62 YLDLF-YRGVAAIGRKASSVAEK------IKAMQKFLGLEVTGKIDSNTMTVIQKPRCGVPD--- 116

  Fly   101 TGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVH 165
              ..|...:| ...:|....:||:|..|...:.:.:||..|.:||.|||:.|.|.|.:..||...
Frog   117 --VERFSHFA-GNPKWGKTTVTYRILNYTPDITKSEVDYAIAQAFRVWSDVTPLNFQKLNSGDAD 178

  Fly   166 IEIKFVESEHGDGDAFDGQGGTLAHAFFPV--FGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGH 228
            |.|.|....|||.|:|||..|.||||:.|.  .|||||||:.|.||:| |.|.|||.||||||||
Frog   179 IMISFNTRAHGDFDSFDGPNGVLAHAYAPSDGIGGDAHFDEDEQWTLG-PTGANLFHVAAHEFGH 242

  Fly   229 SLGLSHSDQSSALMAP---FYRGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYS 289
            |||:|||..::|||.|   |....:|. :||..||.|.||:|||:.    .|:.| |.....|..
Frog   243 SLGMSHSTDTNALMYPTVSFGVTIDPAQYKLSADDIAGIQTLYGKG----NPSQV-PVGKPNPAP 302

  Fly   290 PPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQL----ISKGWPGLPGN 350
            |||  ...:.|..:.......|.:|:...||.:.:::.:.     .:|::    ||..||.: |.
Frog   303 PPK--NQPNKCDPNLTFDAVTSMRGDLLFFKDEVFWRKSA-----RFPEVETIPISIIWPSV-GR 359

  Fly   351 IDAAFTYKNGK--TYFFKGTQYWRYQGRQMDGVYPKEI-SEGFTGIPDHLDAAMVWGGNGKIYFF 412
            :|||:... |:  .|.|||.|:|..:|..:...|||:| |.||......:|||.......|..||
Frog   360 VDAAYEVV-GRDIVYLFKGRQHWATRGWTILPGYPKDIASFGFPKDVKKIDAATFIREEMKAIFF 423

  Fly   413 KGSKFWRF-------DPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHD 470
            .|.:::.:       |..:...:|:.:|       |:...:|||  :.|||.||..|.:...|
Frog   424 VGDRYYSYSHRTSAMDFVRPKKIKSDFP-------GIGKKVDAA--FQNGYLYFSDGARQAEF-- 477

  Fly   471 ARFAVDSATPPFPRPTAHW-WFGCK 494
                 |:......|...:: |..||
Frog   478 -----DNRGKKVVRYLQNYRWMSCK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	16/51 (31%)
		Peptidase_M10	115..268	CDD:278824	78/158 (49%)
		ZnMc_MMP	115..268	CDD:239805	78/158 (49%)
		HX	298..493	CDD:238046	53/209 (25%)
mmp3	NP_001025502.1	PG_binding_1	59..107	CDD:366659	16/51 (31%)
		Peptidase_M10	128..286	CDD:334067	78/158 (49%)
		HX	310..496	CDD:238046	53/208 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020