DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp16a

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_021326042.1	Gene:	mmp16a / 564419	ZFINID:	ZDB-GENE-070820-1	Length:	344	Species:	Danio rerio

Alignment Length:	304	Identity:	98/304 - (32%)
Similarity:	148/304 - (48%)	Gaps:	44/304 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 MAPFYRGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTN-------------VYPATTQRPYSPPK 292
            |||||:..:.. |:|..||...||.:||......:||.             |.|....|...||:
Zfish     1 MAPFYQYMDTENFRLPHDDLQGIQKIYGPPDKLPQPTRPSPTVPPARSHPPVDPRKNDRQTRPPR 65

  Fly   293 VPLDD---------SICKDSKVDTLFNS---AQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWP 345
            :|..|         .||     |..||:   .:.|.:.||...::::..::|..|||.||:..|.
Zfish    66 IPTGDKPTHPNAKPDIC-----DGGFNTLAILRREMFVFKDHWFWRVRDNAVMPGYPMLINVFWR 125

  Fly   346 GLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKI 409
            |||..|||.:....||..||||.|:|.::...:...||::|:....|:| ..::.|:.|....|.
Zfish   126 GLPPKIDAVYENSKGKFVFFKGKQFWVFKDTMLLPGYPQDITMFGNGMPAQSIEMAVWWEDVAKT 190

  Fly   410 YFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAA-LKYTNGYTYFFKGDKYYRFHDARF 473
            |||||.::||::...| .:...|||.|:.|:|||::...| :...||:|||:||.:|::|::.|.
Zfish   191 YFFKGDRYWRYNEDMR-TMDPGYPKSITVWKGVPDSPQGAFVDKANGFTYFYKGKEYWKFNNHRL 254

  Fly   474 AVDSATPPFPRPTAHWWFGCKNTP-------SSTGNIVEGSDNE 510
            .|:   |.:||.....:.||...|       :...|.|...|||
Zfish   255 RVE---PGYPRSILKDFMGCDLVPIDPDLHATEDKNEVIKLDNE 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773
		Peptidase_M10	115..268	CDD:278824	11/26 (42%)
		ZnMc_MMP	115..268	CDD:239805	11/26 (42%)
		HX	298..493	CDD:238046	68/199 (34%)
mmp16a	XP_021326042.1	Peptidase_M10	<1..28	CDD:332519	11/26 (42%)
		HX	79..271	CDD:238046	68/200 (34%)
		DUF3377	284..344	CDD:314687	5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010