DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP17

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_057239.4 Gene:MMP17 / 4326 HGNCID:7163 Length:603 Species:Homo sapiens


Alignment Length:539 Identity:178/539 - (33%)
Similarity:273/539 - (50%) Gaps:66/539 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFA 72
            :.:.:||.....|.|.:......:....:||:|||||.:  :|.:..|..|.....||...|.|.
Human    27 LLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPA--DPTTGQLQTQEELSKAITAMQQFG 89

  Fly    73 GLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDV 137
            ||..||.||..|:.||..|||.:.|......:|.:|.|...::|..:||::::..:|:       
Human    90 GLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPR------- 147

  Fly   138 DAEIGR---------AFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFF 193
            |:.:|.         |..|||:...|.|.........|:|.|.:::|.||..|||.|||:|||||
Human   148 DSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFF 212

  Fly   194 PVF---GGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV- 252
            |..   .||.||||.|.||..|  ..|.:||.||.|||||::||||...:.::|.|:|:|  || 
Human   213 PGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQG--PVG 275

  Fly   253 ----FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKV--PLDDSICKDSKVD----- 306
                :.|..:||..:..|||.:      .:|.|  |.:|..||.:  |.|:......:.|     
Human   276 DPLRYGLPYEDKVRVWQLYGVR------ESVSP--TAQPEEPPLLPEPPDNRSSAPPRKDVPHRC 332

  Fly   307 -TLFNSA---QGETYAFKGDKYYKLTTD----SVEEGYPQLISKGWPGLP---GNIDAAF-TYKN 359
             |.|::.   :||.:.|||..:::||.|    |::   |..:.:.|.|||   .::||.: ...:
Human   333 STHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQ---PAQMHRFWRGLPLHLDSVDAVYERTSD 394

  Fly   360 GKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAK 424
            .|..||||.:||.::...::..||:.:|: |:..|..:|||..|..|.:.||||...:||:|...
Human   395 HKIVFFKGDRYWVFKDNNVEEGYPRPVSD-FSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHT 458

  Fly   425 RPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW 489
            | .:...||.....|.|||:.||.|:::::|.:|||:|.:|::..|....|   .|.:|:.||..
Human   459 R-HMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEV---APGYPQSTARD 519

  Fly   490 WFGCKNTPSSTGNIVEGSD 508
            |..|.:: .:.|::..|.|
Human   520 WLVCGDS-QADGSVAAGVD 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 21/55 (38%)
Peptidase_M10 115..268 CDD:278824 64/171 (37%)
ZnMc_MMP 115..268 CDD:239805 64/171 (37%)
HX 298..493 CDD:238046 66/211 (31%)
MMP17NP_057239.4 PG_binding_1 47..105 CDD:279773 21/59 (36%)
Cysteine switch. /evidence=ECO:0000250 108..115 3/6 (50%)
Peptidase_M10 132..295 CDD:278824 64/171 (37%)
ZnMc_MMP 132..295 CDD:239805 64/171 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..329 8/29 (28%)
HX 329..523 CDD:238046 65/201 (32%)
Hemopexin 1 333..378 13/47 (28%)
Hemopexin 2 382..427 13/45 (29%)
Hemopexin 3 428..475 17/47 (36%)
Hemopexin 4 476..523 17/49 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..571 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40364
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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