DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP16

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_005932.2 Gene:MMP16 / 4325 HGNCID:7162 Length:607 Species:Homo sapiens


Alignment Length:616 Identity:210/616 - (34%)
Similarity:301/616 - (48%) Gaps:101/616 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 SSVFIVVGTLFSIMAAAQSAPVSTTTQ---AEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEE 67
            |.||. :.||..|:.|.    |..|.|   .|::|.::||||.:  :|..|.|....|..||:..
Human    18 SGVFF-LQTLLWILCAT----VCGTEQYFNVEVWLQKYGYLPPT--DPRMSVLRSAETMQSALAA 75

  Fly    68 FQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDS----RSKRYALQGSRWRVKNLTYKISKY 128
            .|.|.|:|:||::|..|:..|..|||||.|:. .|.|    |.|||||.|.:|:.|::||.|...
Human    76 MQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT-RGSSKFHIRRKRYALTGQKWQHKHITYSIKNV 139

  Fly   129 PKRLKRVDVDAEIGRAFAVWSEDTDLTF-----TRKTSG--PVHIEIKFVESEHGDGDAFDGQGG 186
            ..::...:....|.|||.||...|.|||     :...:|  .|.|.|.|....|||...|||:||
Human   140 TPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGG 204

  Fly   187 TLAHAFF--PVFGGDAHFDDAELWTIGSPR--GTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYR 247
            .||||:|  |..|||.|||..|.||:|:|.  |.:||.||.||.||:|||.||:..:|:|||||:
Human   205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQ 269

  Fly   248 GFE-PVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPAT-------------TQRPYSPPKVP---- 294
            ..| ..|||..||...||.:||.......||...|..             ..|| .||:.|    
Human   270 YMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRP-KPPRPPTGRP 333

  Fly   295 ----LDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAF 355
                ...:|| |...:|| ...:.|.:.||...::::..:.|.:|||..|:..|.|||.:|||.:
Human   334 SYPGAKPNIC-DGNFNTL-AILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVY 396

  Fly   356 TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDH-LDAAMVWGGNGKIYFFKGSKFWR 419
            ...:|...||||.:||.::...:...||.::....:|||.| :|:|:.|...||.|||||.::||
Human   397 ENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWR 461

  Fly   420 FDPAKRPPVKASYPKPISNWEGVPNNLDAALKY-TNGYTYFFKGDKYYRFHDARFAVDSATPPFP 483
            :....: .:...|||||:.|:|:|.:...|..: .||:|||:||.:|::|::....|:   |.:|
Human   462 YSEEMK-TMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVE---PGYP 522

  Fly   484 RPTAHWWFGCKNTPSSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAE 548
            |.....:.||   ...|..:.||       ||        ..||.|..:                
Human   523 RSILKDFMGC---DGPTDRVKEG-------HS--------PPDDVDIVI---------------- 553

  Fly   549 RTGNGAMSQSKLTSSSAVSTVITTILMCLVS 579
                      ||.::::....|..::.|:::
Human   554 ----------KLDNTASTVKAIAIVIPCILA 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 21/58 (36%)
Peptidase_M10 115..268 CDD:425668 73/164 (45%)
HX 298..493 CDD:238046 67/196 (34%)
MMP16NP_005932.2 PG_binding_1 46..96 CDD:460223 19/51 (37%)
Cysteine switch. /evidence=ECO:0000250 99..106 5/6 (83%)
Peptidase_M10 126..291 CDD:425668 73/164 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..340 14/59 (24%)
PHA03247 <292..338 CDD:223021 8/46 (17%)
HX 340..532 CDD:238046 67/197 (34%)
Hemopexin 1 340..388 14/49 (29%)
Hemopexin 2 389..434 13/44 (30%)
Hemopexin 3 436..484 20/48 (42%)
Hemopexin 4 485..532 14/49 (29%)
DUF3377 537..607 CDD:463374 11/79 (14%)

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