Protein Alignment Mmp1 and MMP14

DIOPT Version :9

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_004986.1
• Gene: MMP14 / 4323
• HGNCID: 7160
• Length: 582
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 221/601 - (36%)
• Similarity: 312/601 - (51%)
• Gaps: 84/601 - (13%)

  Fly     4 CQSSVFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVS---AI 65
            |.....:.:||..:.:.:|||:..|    .|.:|.|:||||     |.....|.||:..|   ||
Human    10 CLLLPLLTLGTALASLGSAQSSSFS----PEAWLQQYGYLP-----PGDLRTHTQRSPQSLSAAI 65

  Fly    66 EEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGT---GDSRSKRYALQGSRWRVKNLTYKISK 127
            ...|.|.||.:||:.||:|||.|..|||||.|:.|.   .:.|.||||:||.:|:...:|:.|..
Human    66 AAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQN 130

  Fly   128 YPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVH--------IEIKFVESEHGDGDAFDGQ 184
            |..::........|.:||.||...|.|.|.......:.        |.|.|.|..|||...|||:
Human   131 YTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGE 195

  Fly   185 GGTLAHAFF--PVFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPF 245
            ||.||||:|  |..|||.|||.||.||:.:.  .|.::|.||.||.||:|||.||...||:||||
Human   196 GGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPF 260

  Fly   246 YRGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNV--YPATTQRPYSP--PKVP-LDDSICKDSK 304
            |:..:.. |.|.:||:..||.|||.::.  .||.:  .|.||.||..|  ||.| ...:|| |..
Human   261 YQWMDTENFVLPDDDRRGIQQLYGGESG--FPTKMPPQPRTTSRPSVPDKPKNPTYGPNIC-DGN 322

  Fly   305 VDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQ 369
            .||: ...:||.:.||...::::..:.|.:|||..|.:.|.|||.:|:.|:..|:||..||||.:
Human   323 FDTV-AMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDK 386

  Fly   370 YWRYQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYP 433
            :|.:....::..|||.|.|...|:| |.:|||:.|..|||.|||:|:|::||:...| .|.:.||
Human   387 HWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELR-AVDSEYP 450

  Fly   434 KPISNWEGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTP 497
            |.|..|||:|.:...:...::. :|||:||:||::|::.:..|:   |.:|:.....|.||   |
Human   451 KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE---PGYPKSALRDWMGC---P 509

  Fly   498 SSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAMSQSKLTS 562
            |. |...||::.|                            .|.|:.||.|. |.||:
Human   510 SG-GRPDEGTEEE----------------------------TEVIIIEVDEE-GGGAV------- 537

  Fly   563 SSAVSTVITTILMCLV 578
             ||.:.|:..:|:.||
Human   538 -SAAAVVLPVLLLLLV 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	25/58 (43%)
		Peptidase_M10	115..268	CDD:278824	67/165 (41%)
		ZnMc_MMP	115..268	CDD:239805	67/165 (41%)
		HX	298..493	CDD:238046	72/196 (37%)
MMP14	NP_004986.1	PG_binding_1	36..88	CDD:279773	25/56 (45%)
		Peptidase_M10	118..284	CDD:278824	67/165 (41%)
		ZnMc_MMP	118..284	CDD:239805	67/165 (41%)
		HX	316..508	CDD:238046	72/197 (37%)
		DUF3377	<560..582	CDD:288690

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4381
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21040
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2388
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40364
orthoMCL	1	0.900	-	-		OOG6_101521
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900