Protein Alignment Mmp1 and MMP13

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_002418.1
• Gene: MMP13 / 4322
• HGNCID: 7159
• Length: 471
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 174/459 - (37%)
• Similarity: 227/459 - (49%)
• Gaps: 68/459 - (14%)

  Fly    33 AEIYLSQFGYLPAS-----ARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPR 92
            ||.||..: |.|.:     ..|.|||       ....:.|.|||.||.:||:||..|:.:|..||
Human    39 AERYLRSY-YHPTNLAGILKENAASS-------MTERLREMQSFFGLEVTGKLDDNTLDVMKKPR 95

  Fly    93 CGVRDRVGTGDSRSKRYAL--QGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLT 155
            |||.| ||       .|.:  :..:|...||||:|..|...:...:|:....:||.|||:.|.|.
Human    96 CGVPD-VG-------EYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLN 152

  Fly   156 FTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNL 218
            |||...|...|.|.|...||||...|||..|.|||||  .|.:||||||||.|.|| .|.:|.||
Human   153 FTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT-SSSKGYNL 216

  Fly   219 FQVAAHEFGHSLGLSHSDQSSALMAPF--YRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYP 281
            |.||||||||||||.||....|||.|.  |.| :..|.|.:||...||||||.......|
Human   217 FLVAAHEFGHSLGLDHSKDPGALMFPIYTYTG-KSHFMLPDDDVQGIQSLYGPGDEDPNP----- 275

  Fly   282 ATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQ-------L 339
               :.|.:|.|  .|.|:..|:     ..|.:|||..||...:::|        :||       |
Human   276 ---KHPKTPDK--CDPSLSLDA-----ITSLRGETMIFKDRFFWRL--------HPQQVDAELFL 322

  Fly   340 ISKGWPGLPGNIDAAFTYKNGKTYF-FKGTQYWRYQGRQMDGVYPKEISEGFTGIPDH---LDAA 400
            ....||.||..||||:.:.:....| |:|.::|...|..:...|||:|||  .|:|..   :.||
Human   323 TKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISE--LGLPKEVKKISAA 385

  Fly   401 MVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPI-SNWEGVPNNLDAALKYTNGYTYFFKGDK 464
            :.:...||...|.|::.||:|.......| .||:.| .::.|:.:.:||..: .|||.|||.|..
Human   386 VHFEDTGKTLLFSGNQVWRYDDTNHIMDK-DYPRLIEEDFPGIGDKVDAVYE-KNGYIYFFNGPI 448

  Fly   465 YYRF 468
            .:.:
Human   449 QFEY 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	21/59 (36%)
		Peptidase_M10	115..268	CDD:425668	80/156 (51%)
		HX	298..493	CDD:238046	56/183 (31%)
MMP13	NP_002418.1	PG_binding_1	32..91	CDD:460223	21/59 (36%)
		Cysteine switch. /evidence=ECO:0000250	94..101		6/7 (86%)
		Peptidase_M10	112..267	CDD:425668	80/156 (51%)
		Interaction with TIMP2	176..246		44/70 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..284		9/30 (30%)
		Interaction with collagen	268..471		61/212 (29%)
		HX	281..471	CDD:238046	59/191 (31%)