Protein Alignment Mmp1 and MMP12

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_002417.2
• Gene: MMP12 / 4321
• HGNCID: 7158
• Length: 470
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 175/496 - (35%)
• Similarity: 244/496 - (49%)
• Gaps: 54/496 - (10%)

  Fly    18 IMAAAQSA-PVSTTTQ--------AEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAG 73
            :.|.|..| |::::|.        .|.||.:|..|..: :.|.:...:........|:|.|.|.|
Human     9 LQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEIN-KLPVTKMKYSGNLMKEKIQEMQHFLG 72

  Fly    74 LNITGELDAETMKLMSLPRCGVRD----RVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKR 134
            |.:||:||..|:::|..|||||.|    |...|          |..||...:||:|:.|...:.|
Human    73 LKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPG----------GPVWRKHYITYRINNYTPDMNR 127

  Fly   135 VDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VFG 197
            .|||..|.:||.|||..|.|.|::..:|...|.:.|....|||..||||:||.|||||.|  ..|
Human   128 EDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIG 192

  Fly   198 GDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFE-PVFKLDEDDKA 261
            ||||||:.|.||..| .|||||..|.||.||||||.||....|:|.|.|:..: ..|:|..||..
Human   193 GDAHFDEDEFWTTHS-GGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIR 256

  Fly   262 AIQSLYG-RKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYY 325
            .|||||| .|.||..|.   |..::.....|.:..|       .|.|:.|    :.:.|| |:::
Human   257 GIQSLYGDPKENQRLPN---PDNSEPALCDPNLSFD-------AVTTVGN----KIFFFK-DRFF 306

  Fly   326 KLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYK-NGKTYFFKGTQYWRYQGRQMDGVYPKEI-SE 388
            .|......:....|||..||.||..|:||:..: ..:.:.||..:||.....:.:..|||.| |.
Human   307 WLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSF 371

  Fly   389 GFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNLDAALKY 452
            ||......:|||:......:.|||..:::||:| .:|..:...|||.|: |::|:...:||....
Human   372 GFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYD-ERRQMMDPGYPKLITKNFQGIGPKIDAVFYS 435

  Fly   453 TNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGC 493
            .|.|.|||:|...:.:.   |.:...|...   .::.||||
Human   436 KNKYYYFFQGSNQFEYD---FLLQRITKTL---KSNSWFGC 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	17/63 (27%)
		Peptidase_M10	115..268	CDD:425668	76/155 (49%)
		HX	298..493	CDD:238046	56/197 (28%)
MMP12	NP_002417.2	PG_binding_1	28..87	CDD:460223	17/59 (29%)
		Cysteine switch. /evidence=ECO:0000250	90..97		5/6 (83%)
		Peptidase_M10	109..263	CDD:425668	76/154 (49%)
		HX	279..470	CDD:238046	58/209 (28%)
		Hemopexin 1	279..328		14/60 (23%)
		Hemopexin 2	329..375		15/45 (33%)
		Hemopexin 3	377..425		15/48 (31%)
		Hemopexin 4	426..470		12/49 (24%)