DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp1 and MMP10

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_002416.1	Gene:	MMP10 / 4319	HGNCID:	7156	Length:	476	Species:	Homo sapiens

Alignment Length:	492	Identity:	179/492 - (36%)
Similarity:	240/492 - (48%)	Gaps:	52/492 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAE 83
            ::.|.....|....|:.||.::..|....:.....   |....|..|:..|.|.||.:||:||.:
Human    20 LSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRK---DSNLIVKKIQGMQKFLGLEVTGKLDTD 81

  Fly    84 TMKLMSLPRCGVRDRVGTGDSRSKRYALQG-SRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAV 147
            |:::|..|||||.| ||...|      ..| .:||..:|||:|..|...|.|..||:.|.:|..|
Human    82 TLEVMRKPRCGVPD-VGHFSS------FPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKV 139

  Fly   148 WSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVFG--GDAHFDDAELWTI 210
            |.|.|.|||:|...|...|.|.|...||||..:|||.|.:||||:.|..|  ||.||||.|.||
Human   140 WEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT- 203

  Fly   211 GSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV--FKLDEDDKAAIQSLYGRKTNQ 273
            ....|||||.|||||.||||||.||..:.|||.|.|..|..:  |:|.:||...||||||..
Human   204 EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPP--- 265

  Fly   274 LRPTNVYPATTQRPYSPPK-VPLDDSI---CKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEE 334
                   ||:|:.|..|.| ||....:   |..:......::.:|| |.|..|:|:...:....|
Human   266 -------PASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGE-YLFFKDRYFWRRSHWNPE 322

  Fly   335 GYPQLISKGWPGLPGNIDAAFTYKNGKTYF-FKGTQYWRYQGRQMDGVYPKEI-SEGFTGIPDHL 397
            ....|||..||.||..:|||:...:..|.| |||.::|..:|.::...||:.| :.||......:
Human   323 PEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKI 387

  Fly   398 DAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNLDAALKYTNGYTYFFK 461
            |||:......|.|||...|:||||...: .::..:|:.|: ::.||...:||.|: ..|:.|||.
Human   388 DAAVSDKEKKKTYFFAADKYWRFDENSQ-SMEQGFPRLIADDFPGVEPKVDAVLQ-AFGFFYFFS 450

  Fly   462 GDKYYRFHDARFAVDSATPPFPRPTAH-----WWFGC 493
            |...:.|           .|..|...|     .|..|
Human   451 GSSQFEF-----------DPNARMVTHILKSNSWLHC 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	16/55 (29%)
		Peptidase_M10	115..268	CDD:278824	80/156 (51%)
		ZnMc_MMP	115..268	CDD:239805	80/156 (51%)
		HX	298..493	CDD:238046	59/205 (29%)
MMP10	NP_002416.1	PG_binding_1	33..86	CDD:307564	16/55 (29%)
		Cysteine switch. /evidence=ECO:0000250	89..96		6/7 (86%)
		Peptidase_M10	107..263	CDD:306839	80/156 (51%)
		HX	286..476	CDD:238046	59/203 (29%)
		Hemopexin 1	286..335		13/49 (27%)
		Hemopexin 2	336..382		16/45 (36%)
		Hemopexin 3	384..432		14/48 (29%)
		Hemopexin 4	433..476		13/54 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148247
Domainoid	1	1.000	150	1.000	Domainoid score	I4381
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850