Protein Alignment Mmp1 and MMP9

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_004985.2
• Gene: MMP9 / 4318
• HGNCID: 7176
• Length: 707
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 188/709 - (26%)
• Similarity: 241/709 - (33%)
• Gaps: 289/709 - (40%)

  Fly     8 VFIVVGTLFSIMAAAQSAPV---------STTTQ-AEIYLSQFGYLPASARNPASSGLHDQRTWV 62
            |.:|:|..|:.....||..|         .|..| ||.||.::||...:.....|..|.
Human    10 VLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLG------ 68

  Fly    63 SAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRD--RVGT--GDSRSKRYALQGSRWRVKNLTY 123
            .|:...|....|..|||||:.|:|.|..|||||.|  |..|  ||          .:|...|:||
Human    69 PALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGD----------LKWHHHNITY 123

  Fly   124 KISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTL 188
            .|..|.:.|.|..:|....||||:||..|.|||||..|....|.|:|..:|||||..|||:.|.|
Human   124 WIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLL 188

  Fly   189 AHAFFPVFG--GDAHFDDAELWTIGS--------------------------------------- 212
            ||||.|..|  |||||||.|||::|.
Human   189 AHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGL 253

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
Human   254 PWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTA 318

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
Human   319 NYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDK 383

  Fly   213 ------PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFE--PVFKLDEDDKAAIQSLYG- 268
                  .:|.:||.||||||||:|||.||....|||.|.||..|  |:.|   ||...|:.|||
Human   384 KWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHK---DDVNGIRHLYGP 445

  Fly   269 RKTNQLRPTNVYPATTQRPYSPPKV---------------------------------------- 293
            |...:.||..   .||.:|.:||.|
Human   446 RPEPEPRPPT---TTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTV 507

  Fly   294 ---PLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLT--TDSVEEGYPQLISKGWPGLPGNIDA 353
               |:||: |..:..|.:.... .:.|.||..||::.:  ..|..:| |.||:..||.||..:|:
Human   508 PLSPVDDA-CNVNIFDAIAEIG-NQLYLFKDGKYWRFSEGRGSRPQG-PFLIADKWPALPRKLDS 569

  Fly   354 AFTYK-NGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAAMVWG----GNGKIYFFK 413
            .|..: :.|.:||.|.|.|.|.|..:.|  |:.:.:...|    .|.|.|.|    |.||:..|.
Human   570 VFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLG----ADVAQVTGALRSGRGKMLLFS 628

  Fly   414 GSKFWRFDPAKRPPVKASYPKPISNWE------GVPNNLDAALKYTNGYTYFFKGDKYY 466
            |.:.||||      |||....|.|..|      |||.:.....:|..  ..:|..|::|
Human   629 GRRLWRFD------VKAQMVDPRSASEVDRMFPGVPLDTHDVFQYRE--KAYFCQDRFY 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	19/56 (34%)
		Peptidase_M10	115..268	CDD:425668	81/331 (24%)
		HX	298..493	CDD:238046	55/182 (30%)
MMP9	NP_004985.2	Cysteine switch. /evidence=ECO:0000303|PubMed:12077439	97..104		5/6 (83%)
		Peptidase_M10	115..444	CDD:425668	81/331 (24%)
		FN2	223..271	CDD:128373	0/47 (0%)
		FN2	281..329	CDD:128373	0/47 (0%)
		FN2	340..388	CDD:128373	0/47 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..508		16/82 (20%)
		PT	472..506	CDD:282710	0/33 (0%)
		HX	514..704	CDD:238046	56/183 (31%)
		Hemopexin 1	518..563		13/46 (28%)
		Hemopexin 2	564..608		14/49 (29%)
		Hemopexin 3	610..657		18/52 (35%)
		Hemopexin 4	658..704		5/24 (21%)