DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mmp1 and MMP9

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_004985.2 Gene:MMP9 / 4318 HGNCID:7176 Length:707 Species:Homo sapiens


Alignment Length:709 Identity:188/709 - (26%)
Similarity:241/709 - (33%) Gaps:289/709 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VFIVVGTLFSIMAAAQSAPV---------STTTQ-AEIYLSQFGYLPASARNPASSGLHDQRTWV 62
            |.:|:|..|:.....||..|         .|..| ||.||.::||...:.....|..|.      
Human    10 VLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLG------ 68

  Fly    63 SAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRD--RVGT--GDSRSKRYALQGSRWRVKNLTY 123
            .|:...|....|..|||||:.|:|.|..|||||.|  |..|  ||          .:|...|:||
Human    69 PALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGD----------LKWHHHNITY 123

  Fly   124 KISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTL 188
            .|..|.:.|.|..:|....||||:||..|.|||||..|....|.|:|..:|||||..|||:.|.|
Human   124 WIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLL 188

  Fly   189 AHAFFPVFG--GDAHFDDAELWTIGS--------------------------------------- 212
            ||||.|..|  |||||||.|||::|.                                       
Human   189 AHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGL 253

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
Human   254 PWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTA 318

  Fly   213 ----------------------------------------------------------------- 212
                                                                             
Human   319 NYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDK 383

  Fly   213 ------PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFE--PVFKLDEDDKAAIQSLYG- 268
                  .:|.:||.||||||||:|||.||....|||.|.||..|  |:.|   ||...|:.||| 
Human   384 KWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHK---DDVNGIRHLYGP 445

  Fly   269 RKTNQLRPTNVYPATTQRPYSPPKV---------------------------------------- 293
            |...:.||..   .||.:|.:||.|                                        
Human   446 RPEPEPRPPT---TTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTV 507

  Fly   294 ---PLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLT--TDSVEEGYPQLISKGWPGLPGNIDA 353
               |:||: |..:..|.:.... .:.|.||..||::.:  ..|..:| |.||:..||.||..:|:
Human   508 PLSPVDDA-CNVNIFDAIAEIG-NQLYLFKDGKYWRFSEGRGSRPQG-PFLIADKWPALPRKLDS 569

  Fly   354 AFTYK-NGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAAMVWG----GNGKIYFFK 413
            .|..: :.|.:||.|.|.|.|.|..:.|  |:.:.:...|    .|.|.|.|    |.||:..|.
Human   570 VFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLG----ADVAQVTGALRSGRGKMLLFS 628

  Fly   414 GSKFWRFDPAKRPPVKASYPKPISNWE------GVPNNLDAALKYTNGYTYFFKGDKYY 466
            |.:.||||      |||....|.|..|      |||.:.....:|..  ..:|..|::|
Human   629 GRRLWRFD------VKAQMVDPRSASEVDRMFPGVPLDTHDVFQYRE--KAYFCQDRFY 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 19/56 (34%)
Peptidase_M10 115..268 CDD:278824 81/331 (24%)
ZnMc_MMP 115..268 CDD:239805 81/331 (24%)
HX 298..493 CDD:238046 55/182 (30%)
MMP9NP_004985.2 Cysteine switch. /evidence=ECO:0000303|PubMed:12077439 97..104 5/6 (83%)
Peptidase_M10 115..444 CDD:278824 81/331 (24%)
ZnMc_MMP 115..444 CDD:239805 81/331 (24%)
FN2 223..271 CDD:128373 0/47 (0%)
FN2 281..329 CDD:128373 0/47 (0%)
fn2 347..388 CDD:278469 0/40 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..508 16/82 (20%)
PT 472..506 CDD:282710 0/33 (0%)
HX 514..704 CDD:238046 56/183 (31%)
Hemopexin 1 518..563 13/46 (28%)
Hemopexin 2 564..608 14/49 (29%)
Hemopexin 3 610..657 18/52 (35%)
Hemopexin 4 658..704 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

Return to query results.
Submit another query.