Protein Alignment Mmp1 and MMP8

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_011541136.1
• Gene: MMP8 / 4317
• HGNCID: 7175
• Length: 476
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 168/441 - (38%)
• Similarity: 231/441 - (52%)
• Gaps: 39/441 - (8%)

  Fly    36 YLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVG 100
            ||.:|..||::...  |:..:.....|..::|.|.|.|||:||:.:.||:.:|..|||||.|..|
Human    45 YLEKFYQLPSNQYQ--STRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGG 107

  Fly   101 TGDSRSKRYALQ--GSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGP 163
                    :.|.  ..:|...||||:|..|..:|...:|:..|..||.:||..:.|.|||.:.|.
Human   108 --------FMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGE 164

  Fly   164 VHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VFGGDAHFDDAELWTIGSPRGTNLFQVAAHEF 226
            ..|.|.|.:.:|||...|||..|.|||||.|  ..|||||||..|.|| .:....|||.||||||
Human   165 ADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT-NTSANYNLFLVAAHEF 228

  Fly   227 GHSLGLSHSDQSSALMAPFYRGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSP 290
            ||||||:||....|||.|.|...|.. :.|.:||...||::||..:|.::||.  |:|
Human   229 GHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTG--PST------- 284

  Fly   291 PKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAF 355
            || |.|.|:..|: :.||    :||...|| |:|:......::......||..||.||..|.||:
Human   285 PK-PCDPSLTFDA-ITTL----RGEILFFK-DRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAY 342

  Fly   356 -TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIYFFKGSKFW 418
             .:.....:.|||.|||...|..:...|||:||. ||......:|||:.:  ..|.|||...:||
Human   343 EDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFW 405

  Fly   419 RFDPAKRPPVKASYPKPISN-WEGVPNNLDAALKYTNGYTYFFKGDKYYRF 468
            |:| .:|..::..|||.||. :.|:.:.:||..:..: :.:.|.|.:||.|
Human   406 RYD-NQRQFMEPGYPKSISGAFPGIESKVDAVFQQEH-FFHVFSGPRYYAF 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	17/51 (33%)
		Peptidase_M10	115..268	CDD:425668	73/155 (47%)
		HX	298..493	CDD:238046	58/174 (33%)
MMP8	XP_011541136.1	PG_binding_1	45..95	CDD:460223	17/51 (33%)
		Peptidase_M10	116..271	CDD:425668	73/155 (47%)
		HX	285..473	CDD:238046	62/181 (34%)