DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP3

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_002413.1 Gene:MMP3 / 4314 HGNCID:7173 Length:477 Species:Homo sapiens


Alignment Length:449 Identity:169/449 - (37%)
Similarity:226/449 - (50%) Gaps:49/449 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 VSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQG-SRWRVKNLTYKI 125
            |..|.|.|.|.||.:||:||::|:::|..|||||.|   .|..|:    ..| .:||..:|||:|
Human    61 VKKIREMQKFLGLEVTGKLDSDTLEVM
RKPRCGVPD---VGHFRT----FPGIPKWRKTHLTYRI 118

  Fly   126 SKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAH 190
            ..|...|.:..||:.:.:|..||.|.|.|||:|...|...|.|.|...||||...|||.|..|||
Human   119 VNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH 183

  Fly   191 AFFPVFG--GDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV- 252
            |:.|..|  |||||||.|.|| ....|||||.|||||.||||||.||..:.|||.|.|.....: 
Human   184 AYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLT 247

  Fly   253 -FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSP-PKVPLDDSICKDSKVDTLFNSAQGE 315
             |:|.:||...||||||       |....|.|...|..| |..|...:.|..:......::.:||
Human   248 RFRLSQDDINGIQSLYG-------PPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGE 305

  Fly   316 TYAFKGDKYYKLTTDSVEEGYPQ--LISKGWPGLPGNIDAAF--TYKNGKTYFFKGTQYWRYQGR 376
            ...||...:::.:...:|   |:  |||..||.||..:|||:  |.|: ..:.|||.|:|..:|.
Human   306 ILIFKDRHFWRKSLRKLE---PELHLISSFWPSLPSGVDAAYEVTSKD-LVFIFKGNQFWAIRGN 366

  Fly   377 QMDGVYPKEI-SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NW 439
            ::...||:.| :.||......:|||:......|.|||...|:|||| .||..::..:||.|: ::
Human   367 EVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFD-EKRNSMEPGFPKQIAEDF 430

  Fly   440 EGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGC 493
            .|:.:.:||..: ..|:.|||.|.....|           .|..:...|.     |..|
Human   431 PGIDSKIDAVFE-EFGFFYFFTGSSQLEF-----------DPNAKKVTHTLKSNSWLNC 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 12/25 (48%)
Peptidase_M10 115..268 CDD:278824 78/156 (50%)
ZnMc_MMP 115..268 CDD:239805 78/156 (50%)
HX 298..493 CDD:238046 59/205 (29%)
MMP3NP_002413.1 PG_binding_1 25..87 CDD:279773 12/25 (48%)
Cysteine switch. /evidence=ECO:0000250 90..97 6/9 (67%)
Peptidase_M10 108..264 CDD:278824 78/156 (50%)
ZnMc_MMP 108..264 CDD:239805 78/156 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..287 10/31 (32%)
HX 287..477 CDD:238046 59/206 (29%)
Hemopexin 1 287..336 12/51 (24%)
Hemopexin 2 337..383 17/46 (37%)
Hemopexin 3 385..433 17/48 (35%)
Hemopexin 4 434..477 11/54 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148250
Domainoid 1 1.000 150 1.000 Domainoid score I4381
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 1 1.000 - - FOG0000127
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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