Protein Alignment Mmp1 and MMP3

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_002413.1
• Gene: MMP3 / 4314
• HGNCID: 7173
• Length: 477
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 169/449 - (37%)
• Similarity: 226/449 - (50%)
• Gaps: 49/449 - (10%)

  Fly    62 VSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQG-SRWRVKNLTYKI 125
            |..|.|.|.|.||.:||:||::|:::|..|||||.|   .|..|:    ..| .:||..:|||:|
Human    61 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD---VGHFRT----FPGIPKWRKTHLTYRI 118

  Fly   126 SKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAH 190
            ..|...|.:..||:.:.:|..||.|.|.|||:|...|...|.|.|...||||...|||.|..|||
Human   119 VNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH 183

  Fly   191 AFFPVFG--GDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV- 252
            |:.|..|  |||||||.|.|| ....|||||.|||||.||||||.||..:.|||.|.|.....:
Human   184 AYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLT 247

  Fly   253 -FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSP-PKVPLDDSICKDSKVDTLFNSAQGE 315
             |:|.:||...||||||       |....|.|...|..| |..|...:.|..:......::.:||
Human   248 RFRLSQDDINGIQSLYG-------PPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGE 305

  Fly   316 TYAFKGDKYYKLTTDSVEEGYPQ--LISKGWPGLPGNIDAAF--TYKNGKTYFFKGTQYWRYQGR 376
            ...||...:::.:...:|   |:  |||..||.||..:|||:  |.|: ..:.|||.|:|..:|.
Human   306 ILIFKDRHFWRKSLRKLE---PELHLISSFWPSLPSGVDAAYEVTSKD-LVFIFKGNQFWAIRGN 366

  Fly   377 QMDGVYPKEI-SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NW 439
            ::...||:.| :.||......:|||:......|.|||...|:|||| .||..::..:||.|: ::
Human   367 EVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFD-EKRNSMEPGFPKQIAEDF 430

  Fly   440 EGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGC 493
            .|:.:.:||..: ..|:.|||.|.....|           .|..:...|.     |..|
Human   431 PGIDSKIDAVFE-EFGFFYFFTGSSQLEF-----------DPNAKKVTHTLKSNSWLNC 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	12/25 (48%)
		Peptidase_M10	115..268	CDD:425668	78/156 (50%)
		HX	298..493	CDD:238046	59/205 (29%)
MMP3	NP_002413.1	PG_binding_1	25..87	CDD:460223	12/25 (48%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/9 (67%)
		Peptidase_M10	108..264	CDD:425668	78/156 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..287		10/31 (32%)
		HX	287..477	CDD:238046	59/206 (29%)
		Hemopexin 1	287..336		12/51 (24%)
		Hemopexin 2	337..383		17/46 (37%)
		Hemopexin 3	385..433		17/48 (35%)
		Hemopexin 4	434..477		11/54 (20%)