Protein Alignment Mmp1 and mmp14a

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_919397.1
• Gene: mmp14a / 373882
• ZFINID: ZDB-GENE-030901-1
• Length: 574
• Species: Danio rerio
• Alignment Length: 546
• Identity: 202/546 - (36%)
• Similarity: 284/546 - (52%)
• Gaps: 63/546 - (11%)

  Fly     6 SSVFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLP------ASARNPASSGLHDQRTWVSA 64
            :|||:|           ||.......:.|.:|.|:||||      .:.|:|.|..        ||
Zfish    17 ASVFLV-----------QSGTSDKEVRPEAWLQQYGYLPPGDVRAQAIRSPKSIN--------SA 62

  Fly    65 IEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGT---GDSRSKRYALQGSRWRVKNLTYKIS 126
            |...|.|.||.:||.:|..|:..|..|||||.|:.|:   .:.|.|||..|||:|..:.:|:.|.
Zfish    63 ISAMQKFYGLTVTGTMDPATLSAMQRPRCGVPDKFGSELKSNLRKKRYVAQGSKWDKREVTFSIQ 127

  Fly   127 KY-PKRLKRVDVDAEIGRAFAVWSEDTDLTFTR----KTSGPVH----IEIKFVESEHGDGDAFD 182
            .| ||..:|...:| |.:||.||...|.|.|..    :.:|.|.    |.:.|.|..|||...||
Zfish   128 NYTPKVGERATHEA-IKKAFRVWEAVTPLKFREIPYSQINGKVEKFADIMLFFAEGFHGDSTPFD 191

  Fly   183 GQGGTLAHAFFP--VFGGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMA 243
            |:||.||||:||  ..|||.|||:||.||.|:  ..|.::|.||.||.||:|||.||...||:||
Zfish   192 GEGGFLAHAYFPGHGIGGDTHFDEAEPWTTGNVDKGGNDVFLVAVHELGHALGLEHSGDPSAIMA 256

  Fly   244 PFYRGFEPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDT 307
            |||:..:.. |.|.|||:..||.:||..:.. :|....|....|  :|.:......|| :...||
Zfish   257 PFYQWMDTENFVLPEDDRRGIQQIYGAGSED-KPQPPAPRPPTR--TPDRPSFGPDIC-EGHFDT 317

  Fly   308 LFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWR 372
            : ...:||.:.||...::::.....::|||..|...|.|||.:|:||:...:||..||||.:||.
Zfish   318 I-AFLRGEMFVFKEKWFWRVRDGKPQQGYPMPIGHFWKGLPPSINAAYERNDGKFVFFKGDKYWV 381

  Fly   373 YQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPI 436
            :...:|:..|||...|..||:| |.||||:.:...|..|||:|:|::||:...| .|.:.|||.|
Zfish   382 FNEAKMEEGYPKTFKELGTGLPRDKLDAAIFYTPTGNTYFFRGTKYYRFNEESR-SVDSDYPKDI 445

  Fly   437 SNWEGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCK-NTPSS 499
            ..|:|||:|:..|....:| ..||:|.:||::|::.:..|:   |.||:.....|.||: ..|..
Zfish   446 GVWQGVPDNVKGAFMSEDGANAYFYKANKYWKFNNQQLKVE---PGFPKSVLTNWMGCEAEEPKR 507

  Fly   500 TGNIVEGSDNEFEQHSMIPHADDGNG 525
            ..    |:|.|.    :|...|...|
Zfish   508 RA----GTDEEV----LIIEVDGSEG 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	21/61 (34%)
		Peptidase_M10	115..268	CDD:425668	73/166 (44%)
		HX	298..493	CDD:238046	72/196 (37%)
mmp14a	NP_919397.1	PG_binding_1	34..86	CDD:460223	21/59 (36%)
		Peptidase_M10	116..282	CDD:425668	73/166 (44%)
		HX	308..500	CDD:238046	72/197 (37%)
		DUF3377	503..574	CDD:463374	7/31 (23%)