DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp20

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_038931.1	Gene:	Mmp20 / 30800	MGIID:	1353466	Length:	482	Species:	Mus musculus

Alignment Length:	504	Identity:	177/504 - (35%)
Similarity:	243/504 - (48%)	Gaps:	72/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SIMAAAQSAPVSTTTQAEIYLSQF---------GYLPASARNPASSGLHDQRTWVSAIEEFQSFA 72
            :::||......|....|:.||.::         |.:.|...||          .:..|:|.|.|.
Mouse    24 NLLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNP----------MIRRIKELQIFF 78

  Fly    73 GLNITGELDAETMKLMSLPRCGVRD----RVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLK 133
            ||.:||:||..||.::..|||||.|    |:..|:          .:|:...|||:||||...:.
Mouse    79 GLKVTGKLDQNTMNVIKKPRCGVPDVANYRLFPGE----------PKWKKNILTYRISKYTPSMS 133

  Fly   134 RVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VF 196
            ..:||..|..|...||....|.|.|..||...|.|.|...:|||...|||..|||||||.|  ..
Mouse   134 PTEVDKAIQMALHAWSTAVPLNFVRINSGEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGL 198

  Fly   197 GGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-FKLDEDDK 260
            |||.|||:||.||:|: .|.|||.||||||||:|||.||...||||.|.|:...|. |.|.:||.
Mouse   199 GGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPYRFHLPKDDV 262

  Fly   261 AAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSIC-KDSKVDTLFNSAQGETYAFKGDKY 324
            ..||:|||       |..::|.....|:.||..|....:| ..|..|.:  :..|:...|..|:.
Mouse   263 KGIQALYG-------PRKIFPGKPTMPHIPPHKPSIPDLCDSSSSFDAV--TMLGKELLFFKDRI 318

  Fly   325 YKLTTDSVEEGY-PQLISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEIS 387
            :......:..|. |..|:..:|.|..|:|||: ..:.|..:||||..||..:|..|.|. |:.|.
Mouse   319 FWRRQVHLPTGIRPSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFHMQGP-PRTIY 382

  Fly   388 EGFTGIPDH---LDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPI-SNWEGVPNNLDA 448
            :  .|.|.|   :|||:......|..||.|.:::.:|..|: .::..|||.. ..:.||..::||
Mouse   383 D--FGFPRHVQRIDAAVYLKEPQKTLFFVGEEYYSYDERKK-KMEKDYPKNTEEEFSGVSGHIDA 444

  Fly   449 ALKYTNGYTYFFKGDKYYRF----HDARFAVDSATPPFPRPTAHWWFGC 493
            |:: .|||.|||.|.|.:::    .|....|.|::          |.||
Mouse   445 AVE-LNGYIYFFSGRKTFKYDTEKEDVVSVVKSSS----------WIGC 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	19/64 (30%)
		Peptidase_M10	115..268	CDD:278824	78/155 (50%)
		ZnMc_MMP	115..268	CDD:239805	78/155 (50%)
		HX	298..493	CDD:238046	59/205 (29%)
Mmp20	NP_038931.1	PG_binding_1	39..94	CDD:279773	19/64 (30%)
		Cysteine switch. /evidence=ECO:0000250	97..104		5/6 (83%)
		Peptidase_M10	115..270	CDD:278824	78/155 (50%)
		ZnMc_MMP	115..270	CDD:239805	78/155 (50%)
		HX	292..482	CDD:238046	59/206 (29%)
		Hemopexin 1	292..342		10/51 (20%)
		Hemopexin 2	343..388		17/47 (36%)
		Hemopexin 3	390..438		12/48 (25%)
		Hemopexin 4	439..482		15/53 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850