DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp20

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001100270.1	Gene:	Mmp20 / 300341	RGDID:	1308730	Length:	482	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	180/516 - (34%)
Similarity:	247/516 - (47%)	Gaps:	77/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVVGTLFSIMAAAQSAPVSTTTQ-----AEIYLSQF---------GYLPASARNPASSGLHDQRT 60
            :|....|:..|.|..|....|.:     |:.||.::         |.:.|...||.
  Rat    12 LVTALKFATAAPALLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNPT--------- 67

  Fly    61 WVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRD----RVGTGDSRSKRYALQGSRWRVKNL 121
             |..|:|.|:|.||.:||:||..||.::..|||||.|    |:..|:          .:|:...|
  Rat    68 -VRKIKELQTFFGLRVTGKLDQNTMDVIKRPRCGVPDVANYRLFPGE----------PKWKKNIL 121

  Fly   122 TYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGG 186
            ||::|||...:...:||..:..|...||....|.|.|..||...|.|.|...:|||...|||..|
  Rat   122 TYRVSKYTPSMSPTEVDKAVHMALHAWSTAVPLIFVRINSGEADIMISFETGDHGDSYPFDGPRG 186

  Fly   187 TLAHAFFP--VFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGF 249
            ||||||.|  ..|||.|||:||.||:|: .|.|||.||||||||:|||.||...||||.|.|:..
  Rat   187 TLAHAFAPGEGLGGDTHFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQ 250

  Fly   250 EPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSIC-KDSKVDTLFNSA 312
            .|. |.|.:||...||:|||       |...:|.....|:.||..|....:| ..|..|.:  :.
  Rat   251 NPYRFHLPKDDVKGIQALYG-------PRKTFPGKPTMPHIPPHKPSIPDLCDSSSSFDAV--TM 306

  Fly   313 QGETYAFKGDKYYKLTTDSVEEGY-PQLISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQG 375
            .|:...|..|:.:......:..|. |..|:..:|.|..|:|||: ..:.|..:||||..||..:|
  Rat   307 LGKELLFFKDRIFWRRRVHLPAGIRPSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRG 371

  Fly   376 RQMDGVYPKEISEGFTGIPDH---LDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPI- 436
            .||.|. |:.|.:  .|.|.|   :|||:......|..||.|.:::.:|..|: .::..|||..
  Rat   372 FQMQGP-PRTIYD--FGFPRHVQRIDAAVYLKEPQKTLFFVGEEYYSYDERKK-KMEKDYPKSTE 432

  Fly   437 SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRF----HDARFAVDSATPPFPRPTAHWWFGC 493
            ..:.||..::|||:: .|||.|||.|.|.:::    .|....|.|::          |.||
  Rat   433 EEFSGVSGHIDAAVE-LNGYIYFFSGPKTFKYDTEKEDVVSVVKSSS----------WVGC 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	20/69 (29%)
		Peptidase_M10	115..268	CDD:278824	76/155 (49%)
		ZnMc_MMP	115..268	CDD:239805	76/155 (49%)
		HX	298..493	CDD:238046	60/205 (29%)
Mmp20	NP_001100270.1	PG_binding_1	39..94	CDD:279773	20/64 (31%)
		Peptidase_M10	115..270	CDD:278824	76/155 (49%)
		ZnMc_MMP	115..270	CDD:239805	76/155 (49%)
		HX	292..464	CDD:238046	56/178 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850