DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp21

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001099778.1	Gene:	Mmp21 / 293573	RGDID:	1309332	Length:	568	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	177/572 - (30%)
Similarity:	251/572 - (43%)	Gaps:	135/572 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMK 86
            :::.|::....|:.:|.::|:...|:.. .|:|:....|...|:..||....|..:|:||:.|:.
  Rat    42 SRAKPIADLHAAQNFLLKYGWSEVSSPK-ESAGVPVGFTLAQAVRRFQKANRLPASGKLDSPTLA 105

  Fly    87 LMSLPRCGVRD-RVGTGD-----------------SRSKRYALQ-----------------GSR- 115
            .|:.|||||.| |:...|                 :|.||: ||                 .||
  Rat   106 AMNKPRCGVPDTRLPLQDALPTPPALPTPLGLQPRARQKRF-LQMLLPKPGGKQEGRSDTGASRV 169

  Fly   116 WRVKNLTYKI--SKYPKRLKRVDVDAEIGR-AFAVWSEDTDLTFTRKTSGP---VHIEIKFVESE 174
            :..|.||:::  ..|..:|.. |....|.| ||.:|||.|.|.|....:.|   |.|::.|....
  Rat   170 FSKKTLTWRLVGDAYSSQLSG-DEQRYIFRLAFRMWSEVTPLDFREDLTAPGTMVDIKLGFGRGR 233

  Fly   175 H-GDGDAFDGQGGTLAHAFFPVFGGDAHFDDAELWT-IGSPRGTNLFQVAAHEFGHSLGLSHSDQ 237
            | |....|||.|...|||:..   |:.||||.|.:| :.|..|.:|.:||.||.||.|||.|:.:
  Rat   234 HLGCPRVFDGSGQEFAHAWHL---GEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHTYR 295

  Fly   238 SSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKD 302
            ..::|.|.|...||.|:||..|:.|||.|||.                              |:.
  Rat   296 VGSIMQPNYIPQEPAFELDWSDRKAIQRLYGS------------------------------CEG 330

  Fly   303 SKVDTLFN------SAQGE------TYAFKGDKY--YKLTTDSVEEGYPQLISKGWPGLP-GNID 352
            | .|.:|:      :..||      ||.|:...|  |:...:....|.|..|..||.|:| ..||
  Rat   331 S-FDIVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPMQRID 394

  Fly   353 A---AFTYKNGKTYFFKGTQYWRY------------QGRQMDGVYPKEISEGFTGIPDHLDAAMV 402
            |   .:::...:.|||||.|||||            |||.    |||.|||||.|||..||.|..
  Rat   395 AFVHVWSWGRDERYFFKGNQYWRYDSENDQAHTQDEQGRS----YPKLISEGFPGIPSPLDTAFY 455

  Fly   403 WGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW------EGVP-NNLDAA-LKYTNGYTYF 459
            ......|||||.|..:.|| ..|....:||||.:|..      :..| .|||:| ..|.:...:|
  Rat   456 ERRQQLIYFFKESLVYAFD-VNRNQALSSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNAIFF 519

  Fly   460 FKGDKYYRF-------HDARFAVDSATPPFPRPTAHW-WFGCKNTPSSTGNI 503
            |||:.:::.       .|:|..::..   ||:.:... ||...:..:||.|:
  Rat   520 FKGNSFWKVVSDKDKQQDSRLPLNGL---FPKQSVSGKWFDVCDVHTSTLNM 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	15/55 (27%)
		Peptidase_M10	115..268	CDD:278824	63/161 (39%)
		ZnMc_MMP	115..268	CDD:239805	63/161 (39%)
		HX	298..493	CDD:238046	78/240 (33%)
Mmp21	NP_001099778.1	PG_binding_1	48..107	CDD:279773	15/59 (25%)
		Peptidase_M10	170..326	CDD:278824	62/159 (39%)
		ZnMc_MMP	170..326	CDD:239805	62/159 (39%)
		HX	355..544	CDD:238046	68/193 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920