DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp1 and Prg4

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001099432.4	Gene:	Prg4 / 289104	RGDID:	1308976	Length:	1275	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	77/289 - (26%)
Similarity:	113/289 - (39%)	Gaps:	80/289 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 QLRP-TNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGY 336
            :|.| .|::|..:.          :.:||....||.|.....|...||:| .|:.:.........
  Rat   998 RLNPGINIHPMFSD----------ETNICNGKPVDGLTTLRNGTLVAFRG-HYFWMLNPFRPPSP 1051

  Fly   337 PQLISKGWPGLPGNIDAAFTYKN--GKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDA 399
            |:.|::.| |:|..||..||..|  |||:|||.:||||:....||..|||.|.:||.|:...:.|
  Rat  1052 PRRITEVW-GIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDVMDAGYPKLIVKGFGGLTGKIVA 1115

  Fly   400 AM-----------VW----GGNGKIYFFKGS-----------------------KFWRFDPAKRP 426
            |:           |:    |||.:.|.:|..                       :..||:.|..|
  Rat  1116 ALSIAKYKDRPESVYFFKRGGNIQQYTYKQEPVRKCTGRQPAINYSVYGQAAQVRRRRFERAVGP 1180

  Fly   427 ------------PVKASYP---------KPISNWEGVPNNLDAALKYTN-----GYTYF-FKGDK 464
                        |:||||.         |..:.|.|.||.:.:|:...|     ||.|: |..|:
  Rat  1181 FQTHTFRIHYSVPIKASYQDKGFLHNEVKVSTLWRGFPNVVTSAITLPNIRKPDGYDYYAFSKDQ 1245

  Fly   465 YYRFHDARFAVDSATPPFPRPTAHWWFGC 493
            ||..........:.|....:..:..|:.|
  Rat  1246 YYNIDVPTRTARAITTRSGQTLSRVWYNC 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773
		Peptidase_M10	115..268	CDD:278824
		ZnMc_MMP	115..268	CDD:239805
		HX	298..493	CDD:238046	72/261 (28%)
Prg4	NP_001099432.4	SO	26..68	CDD:197571
		SO	67..108	CDD:197571
		PHA03247	<315..724	CDD:223021
		HX	1013..1274	CDD:238046	72/262 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810