DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp23

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_006538942.1	Gene:	Mmp23 / 26561	MGIID:	1347361	Length:	420	Species:	Mus musculus

Alignment Length:	358	Identity:	91/358 - (25%)
Similarity:	132/358 - (36%)	Gaps:	122/358 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 SRSKRYALQGS--RWRVKNLTY-----------------------------KISKYPKR-LKRVD 136
            :|.:||.|..:  ||...||||                             ::..:|:. |...:
Mouse    75 TRRRRYTLTPARLRWDHFNLTYRCHLDQRGGWSGHNSDTNTDSNITAALHHRVLSFPRNLLSPEE 139

  Fly   137 VDAEIGRAFAVWSEDTDLTFTR-KTSGPVHIEIKFVESEHGD------GDAFDGQGGTLAHAFFP 194
            ....:..||.:||:.:..:|.. ....|..::|.|....|.|      ...|||..|.|||||||
Mouse   140 TRRGLAAAFRMWSDVSPFSFREVAPERPSDLKIGFYPVNHTDCLVSAVHHCFDGPTGELAHAFFP 204

  Fly   195 VFGGDAHFDDAELWTIGSPRG--------TNLFQVAAHEFGHSLGLSHSDQSSALM--APFYRGF 249
            ..|| .||||:|.|.:|..|.        |||..|||||.||:|||.||.|..|||  ....||:
Mouse   205 PHGG-IHFDDSEYWVLGPTRYSWKKGVWLTNLVHVAAHEIGHALGLMHSQQDQALMHLNATLRGW 268

  Fly   250 EPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQG 314
            :   .|.:|:...:..|||                               |    :|.:|..|
Mouse   269 K---ALSQDELWGLHRLYG-------------------------------C----LDRIFVCA-- 293

  Fly   315 ETYAFKG-----------------DKYYKL------TTDSVEEGYPQLISKGWPGLPGNIDAAFT 356
             ::|.||                 |..|:.      ||.|......:|:.:| ..:..:......
Mouse   294 -SWARKGFCDVRQRLMKRLCPRSCDFCYEFPFPTVATTTSPTRTKTRLVREG-RNMTFHCGQKIL 356

  Fly   357 YKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEG 389
            :|.||.|::|..:       .::..||..::.|
Mouse   357 HKKGKVYWYKDQE-------PLEFSYPGYLALG 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773
		Peptidase_M10	115..268	CDD:278824	63/199 (32%)
		ZnMc_MMP	115..268	CDD:239805	63/199 (32%)
		HX	298..493	CDD:238046	22/115 (19%)
Mmp23	XP_006538942.1	ZnMc_MMP	88..284	CDD:239805	63/199 (32%)
		ShKT	285..319	CDD:214586	8/40 (20%)
		Ig	343..403	CDD:386229	9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920