Protein Alignment Mmp1 and Mmp11

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_037112.2
• Gene: Mmp11 / 25481
• RGDID: 3099
• Length: 491
• Species: Rattus norvegicus
• Alignment Length: 429
• Identity: 179/429 - (41%)
• Similarity: 231/429 - (53%)
• Gaps: 42/429 - (9%)

  Fly    92 RCGVRD--RVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDL 154
            ||||.|  .|....:|.||:.|.|.||...:|||:|.::|.:|.|..|...:..|..||||.|.|
  Rat    83 RCGVPDPPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALRVWSEVTPL 147

  Fly   155 TFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVF--GGDAHFDDAELWTIGSPRGTN 217
            |||....|...|.|.|....|||...|||.||.|||||||..  .||.|||..|.||||. :||:
  Rat   148 TFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGD-KGTD 211

  Fly   218 LFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPA 282
            |.|||||||||.|||.|:..:.|||:|||. |.....|..||:..||.||||.  ||.||:..|.
  Rat   212 LLQVAAHEFGHVLGLQHTTAAKALMSPFYT-FRYPLSLSPDDRRGIQHLYGRP--QLTPTSPTPT 273

  Fly   283 TT------------QRPYSPPKVPLDDSICKDS--KVDTLFNSAQGETYAFKGDKYYKLTTDSVE 333
            .:            |.|..||:|      |:.|  .|.|:    :||.:.||....::|.:..::
  Rat   274 LSSQAGTDTNEIALQEPEVPPEV------CETSFDAVSTI----RGELFFFKAGFVWRLRSGQLQ 328

  Fly   334 EGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHL 397
            .|||.|.|:.|.|||..:||||....|:.:||:|.|||.|.| :...:.|..:|: |..|.|.|
  Rat   329 PGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDG-EKPVLGPAPLSKLGLQGSPVH- 391

  Fly   398 DAAMVWG-GNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFK 461
             ||:||| ...|||||:|..:|||.| :...|....|:..::|.|||:.:|||.:...||.||.:
  Rat   392 -AALVWGPEKNKIYFFRGGDYWRFHP-RTQRVDNPVPRRTTDWRGVPSEIDAAFQDAEGYAYFLR 454

  Fly   462 GDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSST 500
            |..|::|...:..|   ...||||....:|.|.. |::|
  Rat   455 GHLYWKFDPVKVKV---LESFPRPIGPDFFDCAE-PANT 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223
		Peptidase_M10	115..268	CDD:425668	78/154 (51%)
		HX	298..493	CDD:238046	74/198 (37%)
Mmp11	NP_037112.2	Cysteine switch. /evidence=ECO:0000250	82..89		4/5 (80%)
		Peptidase_M10	108..261	CDD:425668	78/154 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..279		8/20 (40%)
		HX	294..483	CDD:238046	76/205 (37%)
		Hemopexin 1	298..342		14/47 (30%)
		Hemopexin 2	343..385		16/42 (38%)
		Hemopexin 3	387..435		21/50 (42%)
		Hemopexin 4	436..483		17/49 (35%)