DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp7

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_036996.1	Gene:	Mmp7 / 25335	RGDID:	3100	Length:	267	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	111/284 - (39%)
Similarity:	138/284 - (48%)	Gaps:	27/284 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNCQSSVFIVVGTLFSIMAAAQSAPVSTTT-----QAEIYLSQFGYLPASARNPASSGLHDQRT 60
            |...:.::|.:|..|...:|...|......|     ||:.||.:| ||..|....|:|.
  Rat     1 MAAMRLTLFRIVCLLPGCLALPLSQEAGEVTALQWEQAQNYLRKF-YLHDSKTKKATSA------ 58

  Fly    61 WVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYAL--QGSRWRVKNLTY 123
             |..:.|.|.|.||..||:|....|::|..|||||.|        ...::|  ...:|..:.:||
  Rat    59 -VDKLREMQKFFGLPETGKLSPRVMEIMQKPRCGVPD--------VAEFSLMPNSPKWHSRTVTY 114

  Fly   124 KISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTL 188
            :|..|...|.|..||..:.||..:||....|.|.|.:.|...|.|.|...:|||...|||.|.||
  Rat   115 RIVSYTTDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIGFARGDHGDNFPFDGPGNTL 179

  Fly   189 AHAFF--PVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRG-FE 250
            .|||.  |..|||||||..|.||.|...|.|...||.||.||||||.||...|::|.|.|:| ..
  Rat   180 GHAFAPGPGLGGDAHFDKDEYWTDGEDSGVNFLFVATHELGHSLGLGHSSVPSSVMYPTYQGDHS 244

  Fly   251 PVFKLDEDDKAAIQSLYGRKTNQL 274
            ..|.|.:||.|.||.||| |.|:|
  Rat   245 EDFSLTKDDIAGIQKLYG-KRNKL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	20/55 (36%)
		Peptidase_M10	115..268	CDD:278824	71/155 (46%)
		ZnMc_MMP	115..268	CDD:239805	71/155 (46%)
		HX	298..493	CDD:238046
Mmp7	NP_036996.1	PG_binding_1	34..85	CDD:396175	20/58 (34%)
		Cysteine switch. /evidence=ECO:0000250	88..95		6/14 (43%)
		Peptidase_M10	106..262	CDD:395334	71/155 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920