Protein Alignment Mmp1 and Mmp25

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001028511.1
• Gene: Mmp25 / 240047
• MGIID: 2443938
• Length: 615
• Species: Mus musculus
• Alignment Length: 572
• Identity: 190/572 - (33%)
• Similarity: 278/572 - (48%)
• Gaps: 84/572 - (14%)

  Fly    22 AQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMK 86
            ||:......:....:|:::||||.:  :|..:.:........||:..|.||||..||::|..|:|
Mouse    76 AQNPDAKVVSMGVEWLTRYGYLPPA--DPVHAQMQSLEKLQDAIKVMQRFAGLPETGQMDPMTIK 138

  Fly    87 LMSLPRCGVRDRVGTGD--SRSKRYALQGSRWRVKNLTYKISKYPKR--LKRVDVDAEIGRAFAV 147
            .|..|||.:.|.:|...  .|.:||:|.||.|:.:.||:.|..:.::  |....|...:..|.||
Mouse   139 TMRKPRCSLPDVLGAAGLVRRRRRYSLSGSVWKKRTLTWSIRSFSQKSQLSPQIVRTLLSYALAV 203

  Fly   148 WSEDTDLTFTRKTS--GPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP---VFGGDAHFDDAEL 207
            |:.::.|||....|  ....|.|.|..:.|.|...|||.||||||||||   ...||.||||.|.
Mouse   204 WATESGLTFQEVNSQYQEPDIIIHFARAYHQDSYPFDGSGGTLAHAFFPGEHPISGDTHFDDEET 268

  Fly   208 WTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-----FKLDEDDKAAIQS 265
            ||.||  ..|.:||.||.|||||:|||.||...:::|.|||:|  ||     ::|.:||:..:|.
Mouse   269 WTFGSTDDNGIDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQG--PVGDPATYRLPQDDRDGLQQ 331

  Fly   266 LYGR--KTNQLRPTN--VYPATTQRPYSPPKVPLDDSI------CKDSKVDTLFNSAQGETYAFK 320
            ||||  :....|||.  :.|     |..||.:|.|...      | :...|.:.| .:||.:.||
Mouse   332 LYGRVSQNPNARPTRKPLVP-----PPQPPAMPPDSPATPVPDRC-EGNFDAVAN-IRGEIFLFK 389

  Fly   321 GDKYYKLTTDSVEEGYPQLIS-------KGWPGLPGN---IDAAFTYK-NGKTYFFKGTQYWRYQ 374
            |..:::|....      ||:|       :.|.|||.:   |.||:... :|:...|.|.|:|.:|
Mouse   390 GPWFWRLQPSG------QLVSPRPAGLHRFWEGLPTHVKVIQAAYARPLDGRIILFSGPQFWVFQ 448

  Fly   375 GRQMDGVYPKEISEGFTGIP--DHLDAAMVWGGNGKIYFFKGSKFWRFDP-AKRPPVKASYPKPI 436
            .||::|. .:.:.|  .|:|  :.:||...|..|||.|..:|.|:||:|. |.||  ...||:.:
Mouse   449 ERQLEGA-ARPLVE--FGLPPGEDVDAVFSWPHNGKTYLIRGQKYWRYDEVAARP--DPGYPRAL 508

  Fly   437 SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTG 501
            |.|:|.|...|.......|.||||||..::||.:.....:|.:   |:|....|..|. .|:|..
Mouse   509 SLWDGAPFAPDDVTISNTGDTYFFKGTHFWRFAEGSVKAESDS---PQPIGPKWLDCP-APNSDP 569

  Fly   502 NIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDE------PIVPEVA 547
            .:........:..|...|.:            .:|::::      |::|.||
Mouse   570 RVTSPPKTTSKTRSCDCHCE------------LNQASEQLSPLLLPLLPLVA 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	18/55 (33%)
		Peptidase_M10	115..268	CDD:425668	70/166 (42%)
		HX	298..493	CDD:238046	66/214 (31%)
Mmp25	NP_001028511.1	PG_binding_1	89..140	CDD:460223	18/52 (35%)
		Cysteine switch. /evidence=ECO:0000250	143..150		3/6 (50%)
		ZnMc_MMP	170..334	CDD:239805	70/165 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..366		9/34 (26%)
		HX	368..562	CDD:238046	66/209 (32%)
		Hemopexin 1	368..417		13/56 (23%)
		Hemopexin 2	421..466		14/47 (30%)
		Hemopexin 3	467..515		20/49 (41%)
		Hemopexin 4	516..562		14/48 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..582		7/38 (18%)