Protein Alignment Mmp1 and Mmp21

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_694423.1
• Gene: Mmp21 / 214766
• MGIID: 2664387
• Length: 568
• Species: Mus musculus
• Alignment Length: 573
• Identity: 181/573 - (31%)
• Similarity: 252/573 - (43%)
• Gaps: 137/573 - (23%)

  Fly    22 AQSAPVSTTTQAEIYLSQFGY--LPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAET 84
            :|:.|::....|:.:|.::|:  :|:...   |:|:....|...|:..||....|..:||||:.|
Mouse    42 SQAKPIADLHDAQSFLLKYGWSEIPSPKE---SAGVPVGFTLAQAVRRFQKANRLPASGELDSPT 103

  Fly    85 MKLMSLPRCGVRDR---------------VGTG---DSRSKRYALQ-----------------GS 114
            :..|:.|||||.|.               ...|   .:|.||: ||                 .|
Mouse   104 LAAMNKPRCGVPDTRLPPRAALPTPPALLTSLGLRPRARQKRF-LQMLFPKPDGQQEDASDTGAS 167

  Fly   115 R-WRVKNLTYKI--SKYPKRLKRVDVDAEIGR-AFAVWSEDTDLTFTRKTSGP---VHIEIKFVE 172
            | :..|.||:::  ..|..:|.. |....|.| ||.:|||.|.|.|....:.|   |.|::.|..
Mouse   168 RAFSKKTLTWRLVGDAYSSQLSG-DEQRYIFRLAFRMWSEVTPLDFREDRTAPGTMVDIKLGFGR 231

  Fly   173 SEH-GDGDAFDGQGGTLAHAFFPVFGGDAHFDDAELWT-IGSPRGTNLFQVAAHEFGHSLGLSHS 235
            ..| |....|||.|...|||:..   |:.||||.|.:| :.|..|.:|.:||.||.||.|||.|:
Mouse   232 GRHLGCPRVFDGSGQEFAHAWRL---GEIHFDDDEHFTPLSSDTGISLLKVAVHEIGHVLGLPHT 293

  Fly   236 DQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSIC 300
            .:..::|.|.|...||.|:||..|:.|||.|||.                              |
Mouse   294 YRVGSIMQPNYIPQEPAFELDWADRKAIQRLYGS------------------------------C 328

  Fly   301 KDSKVDTLFN------SAQGE------TYAFKGDKY--YKLTTDSVEEGYPQLISKGWPGLP-GN 350
            |.| .||:|:      :..||      ||.|:...|  |:...:....|.|..|..||.|:| .:
Mouse   329 KGS-FDTVFDWIRKERNQYGEVRVRFNTYFFRNSWYWLYENRNNRTRYGDPLQILTGWRGIPTQS 392

  Fly   351 IDA---AFTYKNGKTYFFKGTQYWRY------------QGRQMDGVYPKEISEGFTGIPDHLDAA 400
            |||   .:::...:.|||||:|||||            |||.    |||.|||||.|||..||.|
Mouse   393 IDAYVHVWSWGKDERYFFKGSQYWRYDSENDQAHTEDEQGRS----YPKLISEGFPGIPSPLDTA 453

  Fly   401 MVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW------EGVP-NNLDAA-LKYTNGYT 457
            ........|||||.|..:.|| ..|..|..||||.:|..      :..| .|||:| ..|.:...
Mouse   454 FYDRRQQLIYFFKESLVFAFD-VNRNQVLNSYPKKMSQVFPAIMPQNHPFRNLDSAYYSYAHNSI 517

  Fly   458 YFFKGDKYYRF-------HDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNI 503
            :||||:.|::.       .:.|..::...|  .:|.:..||...:..:||.|:
Mouse   518 FFFKGNSYWKVVSDKDKQQNTRLPLNGLFP--KKPVSEKWFDVCDVHTSTLNM 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	16/57 (28%)
		Peptidase_M10	115..268	CDD:425668	63/161 (39%)
		HX	298..493	CDD:238046	81/239 (34%)
Mmp21	NP_694423.1	PG_binding_1	48..107	CDD:460223	16/61 (26%)
		Cysteine switch. /evidence=ECO:0000250	110..117		5/6 (83%)
		ZnMc_MMP	170..326	CDD:239805	62/159 (39%)
		HX	328..544	CDD:238046	77/221 (35%)
		Hemopexin 1	329..388		17/59 (29%)
		Hemopexin 2	390..446		24/59 (41%)
		Hemopexin 3	447..495		19/48 (40%)
		Hemopexin 4	502..558		15/57 (26%)