DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp7

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_034940.2	Gene:	Mmp7 / 17393	MGIID:	103189	Length:	267	Species:	Mus musculus

Alignment Length:	285	Identity:	107/285 - (37%)
Similarity:	139/285 - (48%)	Gaps:	36/285 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTNCQSSVFIVVGTL---FSIMAAAQSAPVST--TTQAEIYLSQFGYLPASARNPASSGLHDQRT 60
            |...|.::|..|..|   .::..:.::..||.  ..||:.||.:|  .|           ||.:|
Mouse     1 MAAMQLTLFCFVCLLPGHLALPLSQEAGDVSAHQWEQAQNYLRKF--YP-----------HDSKT 52

  Fly    61 -----WVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYAL--QGSRWRV 118
                 .|..::|.|.|.||.:||:|....|::|..|||||.|        ...|:|  ...:|..
Mouse    53 KKVNSLVDNLKEMQKFFGLPMTGKLSPYIMEIMQKPRCGVPD--------VAEYSLMPNSPKWHS 109

  Fly   119 KNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDG 183
            :.:||:|..|...|.|:.||..:.:|..:||....|.|.|.:.|...|.|.|...:|||...|||
Mouse   110 RIVTYRIVSYTSDLPRIVVDQIVKKALRMWSMQIPLNFKRVSWGTADIIIGFARRDHGDSFPFDG 174

  Fly   184 QGGTLAHAFF--PVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFY 246
            .|.||.|||.  |..|||||||..|.||.|...|.|....|.||||||||||||.....:|.|.|
Mouse   175 PGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDAGVNFLFAATHEFGHSLGLSHSSVPGTVMYPTY 239

  Fly   247 -RGFEPVFKLDEDDKAAIQSLYGRK 270
             |.:...|.|.:||.|.||.|||::
Mouse   240 QRDYSEDFSLTKDDIAGIQKLYGKR 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	19/60 (32%)
		Peptidase_M10	115..268	CDD:278824	70/155 (45%)
		ZnMc_MMP	115..268	CDD:239805	70/155 (45%)
		HX	298..493	CDD:238046
Mmp7	NP_034940.2	PG_binding_1	34..85	CDD:279773	19/63 (30%)
		Peptidase_M10	106..262	CDD:278824	70/155 (45%)
		ZnMc_MMP	106..262	CDD:239805	70/155 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4397
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920