DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp24

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_034938.3	Gene:	Mmp24 / 17391	MGIID:	1341867	Length:	618	Species:	Mus musculus

Alignment Length:	609	Identity:	213/609 - (34%)
Similarity:	301/609 - (49%)	Gaps:	100/609 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LFSIMAAAQSAPVSTTTQAEIYLSQFGY-LPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITG 78
            |.:...|.:.|........:.:|..:|| ||..:|   :|.||..:...||:...|.|.|:.:||
Mouse    36 LAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESR---ASALHSGKALQSAVSTMQQFYGIPVTG 97

  Fly    79 ELDAETMKLMSLPRCGVRDRVG-TGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIG 142
            .||..|::.|..|||||.|... :...|:|||||.|.:||.|::||.|..|..::..:|....|.
Mouse    98 VLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIR 162

  Fly   143 RAFAVWSEDTDLTFTRKTSGPVHIEIK-----------FVESEHGDGDAFDGQGGTLAHAFF--P 194
            :||.||.:.|.|||...   |.| |||           |....|||...|||:||.||||:|  |
Mouse   163 QAFDVWQKVTPLTFEEV---PYH-EIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGP 223

  Fly   195 VFGGDAHFDDAELWTIGSPR--GTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLD 256
            ..|||.|||..|.||:|:..  |.:||.||.||.||:|||.||:..||:|||||:..|. .|||.
Mouse   224 GIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLP 288

  Fly   257 EDDKAAIQSLYGRKTNQLRPTNVYP--------ATTQRPYS----PPKVPLDD---------SIC 300
            :||...||.:||.....|.||...|        :.::|.:.    ||:.||.|         :||
Mouse   289 QDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRPPRPPLGDRPSTPGAKPNIC 353

  Fly   301 KDSKVDTLFNSA---QGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKT 362
                 |..||:.   :||.:.||...:::|..:.|:||||..|.:.|.|||..||||:...:|:.
Mouse   354 -----DGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRF 413

  Fly   363 YFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRP 426
            .||||.:||.::...::..||..:.|..:.:| :.:|.|:.|...||.|||||.::||:...:|
Mouse   414 VFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERR- 477

  Fly   427 PVKASYPKPISNWEGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWW 490
            .....|||||:.|:|:|.....|.....| ||||:||..|::|.:.:.:|:   |.:||.....|
Mouse   478 ATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVE---PGYPRNILRDW 539

  Fly   491 FGCKNTPSSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAM 555
            .|||.           .:.|..:...:|.      ||.|..|   ..:|.|
Mouse   540 MGCKQ-----------KEVERRKERRLPQ------DDVDIMV---TIDDVP-------------- 570

  Fly   556 SQSKLTSSSAVSTVI-TTILMCLV 578
                 .|.:||:.|: .|:.:||:
Mouse   571 -----GSVNAVAVVVPCTLSLCLL 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	19/56 (34%)
		Peptidase_M10	115..268	CDD:278824	76/168 (45%)
		ZnMc_MMP	115..268	CDD:239805	76/168 (45%)
		HX	298..493	CDD:238046	71/199 (36%)
Mmp24	NP_034938.3	PG_binding_1	55..107	CDD:307564	19/54 (35%)
		Cysteine switch. /evidence=ECO:0000250	110..117		5/6 (83%)
		Peptidase_M10	135..300	CDD:306839	76/168 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..352		13/55 (24%)
		HX	350..542	CDD:238046	71/200 (36%)
		Hemopexin 1	350..398		17/52 (33%)
		Hemopexin 2	399..444		15/44 (34%)
		Hemopexin 3	446..494		20/48 (42%)
		Hemopexin 4	495..542		15/49 (31%)
		DUF3377	548..618	CDD:314687	15/70 (21%)
		PDZ-binding	616..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2400
Isobase	1	0.950	-	0	Normalized mean entropy	S5393
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42430
orthoMCL	1	0.900	-	-		OOG6_101521
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850