DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp2

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_006530814.1	Gene:	Mmp2 / 17390	MGIID:	97009	Length:	704	Species:	Mus musculus

Alignment Length:	726	Identity:	176/726 - (24%)
Similarity:	242/726 - (33%)	Gaps:	280/726 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVGTLFSIMAAAQSAP---------VSTTTQAEI---YLSQFGYLPASARNPASSGLHDQRTWV- 62
            |:..|..::..|.:||         |:..|..|:   ||:.|...|..:.|          .:|
Mouse    16 VLCVLCCLLGRAIAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCN----------LFVL 70

  Fly    63 -SAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKIS 126
             ..:::.|.|.||..||:||..|::.|..|||      |..|..:..:..:..:|....:||:|.
Mouse    71 KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC------GNPDVANYNFFPRKPKWDKNQITYRII 129

  Fly   127 KYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHA 191
            .|...|....||....||..|||:.|.|.|:|...|...|.|.|...|||||..|||:.|.||||
Mouse   130 GYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHA 194

  Fly   192 FFP--VFGGDAHFDDAELWTIGS------------------------------------------ 212
            |.|  ..|||:||||.||||:|.
Mouse   195 FAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWC 259

  Fly   213 ----------------------------------------------------------------- 212

Mouse   260 STTYNFEKDGKYGFCPHEDPTHGLTHGRADLLHHRLLSSALFMLLSRKLNFVVRLKLLTITLFTM 324

  Fly   213 ----------------------------------------------------------------- 212

Mouse   325 GGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGA 389

  Fly   213 --------------------------------------------PRGTNLFQVAAHEFGHSLGLS 233
                                                        .:|.:||.||||||||::||.
Mouse   390 PCVFPFTFLGNKYESCTSAGRNDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLE 454

  Fly   234 HSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDS 298
            ||....|||||.|. :...|:|..||...||.|||...:....|...|..|..|.:|       .
Mouse   455 HSQDPGALMAPIYT-YTKNFRLSHDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTP-------E 511

  Fly   299 ICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAF-TYKNGKT 362
            |||...|.......:||.:.||....::..|...:...|.|::..||.||..|||.: ..:..|.
Mouse   512 ICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKA 576

  Fly   363 YFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP---DHLDAAMVWGGNGKIYFFKGSKFWRFDPAK 424
            .||.|.:||.|....::..|||.::.  .|:|   ..:|||..|..|.|.|.|.|.||||::..|
Mouse   577 VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQQVDAAFNWSKNKKTYIFAGDKFWRYNEVK 639

  Fly   425 RPPVKASYPKPIS-NWEGVPNNLDAALKYT-NGYTYFFKGDKYYRFHD-----ARFAVDSATPPF 482
            : .:...:||.|: :|..:|:||||.:... .|::|||||..|.:..:     .:|....:.
Mouse   640 K-KMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSD--- 700

  Fly   483 PRPTAHWWFGC 493
                   |.||
Mouse   701 -------WLGC 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	16/60 (27%)
		Peptidase_M10	115..268	CDD:278824	76/370 (21%)
		ZnMc_MMP	115..268	CDD:239805	76/370 (21%)
		HX	298..493	CDD:238046	62/205 (30%)
Mmp2	XP_006530814.1	PG_binding_1	<70..97	CDD:366659	9/26 (35%)
		Peptidase_M10	118..>219	CDD:334067	48/100 (48%)
		FN2	226..274	CDD:128373	0/47 (0%)
		FN2	326..374	CDD:128373	0/47 (0%)
		FN2	384..432	CDD:128373	0/47 (0%)
		ZnMc	<408..489	CDD:214576	29/81 (36%)
		HX	510..704	CDD:238046	63/213 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920