Protein Alignment Mmp1 and Mmp16

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_062698.2
• Gene: Mmp16 / 17389
• MGIID: 1276107
• Length: 607
• Species: Mus musculus
• Alignment Length: 622
• Identity: 208/622 - (33%)
• Similarity: 302/622 - (48%)
• Gaps: 111/622 - (17%)

  Fly     5 QSSVFIVVGTLFSIMAAAQSAPVSTTTQ---AEIYLSQFGYLPASARNPASSGLHDQRTWVSAIE 66
            :|.||. :.||..|:.|.    |..|.|   .|::|.::||||.:  :|..|.|....|..||:.
Mouse    17 RSGVFF-LQTLLWILCAT----VCGTEQYFNVEVWLQKYGYLPPT--DPRMSVLRSAETMQSALA 74

  Fly    67 EFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDS----RSKRYALQGSRWRVKNLTYKISK 127
            ..|.|.|:|:||::|..|:..|..|||||.|:. .|.|    |.|||||.|.:|:.|::||.|..
Mouse    75 AMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT-RGSSKFNIRRKRYALTGQKWQHKHITYSIKN 138

  Fly   128 YPKRLKRVDVDAEIGRAFAVWSEDTDLTF-----TRKTSG--PVHIEIKFVESEHGDGDAFDGQG 185
            ...::...:....|.|||.||...|.|||     :...:|  .|.|.|.|....|||...|||:|
Mouse   139 VTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEG 203

  Fly   186 GTLAHAFF--PVFGGDAHFDDAELWTIGSPR--GTNLFQVAAHEFGHSLGLSHSDQSSALMAPFY 246
            |.||||:|  |..|||.|||..|.||:|:|.  |.:||.||.||.||:|||.||:..:|:|||||
Mouse   204 GFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFY 268

  Fly   247 RGFE-PVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPP--KVPLDD----------- 297
            :..| ..|||..||...||.:||      .|..:.|.|...|..||  .||..|
Mouse   269 QYMETDNFKLPNDDLQGIQKIYG------PPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPR 327

  Fly   298 -------------SICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPG 349
                         :|| |...:|| ...:.|.:.||...::::..:.|.:|||..|:..|.|||.
Mouse   328 PPTGRPSYPGAKPNIC-DGNFNTL-AILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPP 390

  Fly   350 NIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDH-LDAAMVWGGNGKIYFFK 413
            :|||.:...:|...||||.:||.::...:...||.::.....|||.| :|:|:.|...||.||||
Mouse   391 SIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGKTYFFK 455

  Fly   414 GSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKY-TNGYTYFFKGDKYYRFHDARFAVDS 477
            |.::||:....: .:...|||||:.|:|:|.:...|..: .||:|||:||.:|::|::....|:
Mouse   456 GDRYWRYSEEMK-TMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVE- 518

  Fly   478 ATPPFPRPTAHWWFGCKNTPSSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPI 542
              |.:||.....:.||           :|..:..::....|       ||.|..:
Mouse   519 --PGYPRSILKDFMGC-----------DGPTDRDKEGLSPP-------DDVDIVI---------- 553

  Fly   543 VPEVAERTGNGAMSQSKLTSSSAVSTVITTILMCLVS 579
                            ||.::::....|..::.|:::
Mouse   554 ----------------KLDNTASTVKAIAIVIPCILA 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	21/58 (36%)
		Peptidase_M10	115..268	CDD:425668	73/164 (45%)
		HX	298..493	CDD:238046	67/196 (34%)
Mmp16	NP_062698.2	PG_binding_1	46..96	CDD:460223	19/51 (37%)
		Cysteine switch. /evidence=ECO:0000250	99..106		5/6 (83%)
		Peptidase_M10	126..291	CDD:425668	73/164 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..340		15/64 (23%)
		PHA03247	<292..338	CDD:223021	9/45 (20%)
		HX	340..532	CDD:238046	67/197 (34%)
		Hemopexin 1	340..388		14/49 (29%)
		Hemopexin 2	389..434		13/44 (30%)
		Hemopexin 3	436..484		20/48 (42%)
		Hemopexin 4	485..532		14/49 (29%)
		DUF3377	537..607	CDD:463374	8/71 (11%)