DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and Mmp15

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_032635.1 Gene:Mmp15 / 17388 MGIID:109320 Length:657 Species:Mus musculus


Alignment Length:647 Identity:213/647 - (32%)
Similarity:298/647 - (46%) Gaps:105/647 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NCQSSVFIVVGTLFSIM------AAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTW 61
            :|.||...::..|..::      .|::.|.|..   ||.:|..:||||..:|:  .|.:...:..
Mouse    16 SCLSSRASLLPLLLVLLDCLGHGTASKDAEVYA---AENWLRLYGYLPQPSRH--MSTMRSAQIL 75

  Fly    62 VSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTG-----DSRSKRYALQGSRWRVKNL 121
            .||:.|.|||.|:.:||.||.||...|..|||||.|:.|..     ..|.|||.|.|..|...:|
Mouse    76 ASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHL 140

  Fly   122 TYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTR--------KTSGPVHIEIKFVESEHGDG 178
            |:.|..|.::|...:....:.|||.||.:.|.|.|..        :......|.:.|....|||.
Mouse   141 TFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDS 205

  Fly   179 DAFDGQGGTLAHAFF--PVFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSS 239
            ..|||.||.||||:|  |..|||.|||..|.||..|.  .|.:||.||.||.||:|||.||...|
Mouse   206 SPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPS 270

  Fly   240 ALMAPFYRGFE-PVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRP-------YSPPKVP-- 294
            |:|||||:..: ..|:|.|||...||.|||....:.:||.  |..|.||       :.||:.|  
Mouse   271 AIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTR--PLPTVRPRRPGRPDHQPPRPPQP 333

  Fly   295 ---------------------------LDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSV 332
                                       ...:|| |...||: ...:||.:.|||..::::..:.|
Mouse   334 PHPGGKPERPPKPGPPPQPRATERPDQYGPNIC-DGNFDTV-AVLRGEMFVFKGRWFWRVRHNRV 396

  Fly   333 EEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP-DH 396
            .:.||..|...|.||||||.||:..::|...||||.:||.::...::..||:.:|...|.|| |.
Mouse   397 LDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDR 461

  Fly   397 LDAAMVWGGNGKIYFFKGSKFWRF-------DPAKRPPVKASYPKPISNWEGVPNNLDAA-LKYT 453
            :|.|:.|...|..:||:..::|||       ||        .||||||.|:|:|.:...| |...
Mouse   462 IDTAIWWEPTGHTFFFQADRYWRFNEETQHGDP--------GYPKPISVWQGIPTSPKGAFLSND 518

  Fly   454 NGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNIVEGSDNEFEQH-SMI 517
            ..||||:||.||::|::.|..::   |..|:.....:.||:..........:.:...|..: ...
Mouse   519 AAYTYFYKGTKYWKFNNERLRME---PGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPNGGAE 580

  Fly   518 PHADDGNGDDFDAAVGDHQSNDEPIVP-EVAERTGNGAMSQSKLTSSSAVSTVITTILMCLV 578
            |.||   ||..:...||.......:|. |...||.|..|           ..|...:|:|::
Mouse   581 PEAD---GDSKEENAGDKDEGSRVVVQMEEVVRTVNVVM-----------VLVPLLLLLCIL 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 22/55 (40%)
Peptidase_M10 115..268 CDD:425668 69/165 (42%)
HX 298..493 CDD:238046 71/203 (35%)
Mmp15NP_032635.1 PG_binding_1 42..102 CDD:460223 24/64 (38%)
Cysteine switch. /evidence=ECO:0000250 105..112 5/6 (83%)
Peptidase_M10 134..300 CDD:425668 69/165 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 14/71 (20%)
HX 363..555 CDD:238046 71/204 (35%)
Hemopexin 1 363..411 15/49 (31%)
Hemopexin 2 412..457 17/44 (39%)
Hemopexin 3 459..507 20/55 (36%)
Hemopexin 4 508..555 14/49 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..599 8/40 (20%)
DUF3377 <632..657 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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