DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and Mmp14

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_032634.3 Gene:Mmp14 / 17387 MGIID:101900 Length:582 Species:Mus musculus


Alignment Length:595 Identity:219/595 - (36%)
Similarity:309/595 - (51%) Gaps:84/595 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVS---AIEEFQSF 71
            :.:||..:.:..||.:..|    .|.:|.|:||||     |.....|.||:..|   ||...|.|
Mouse    16 LTLGTALASLGWAQGSNFS----PEAWLQQYGYLP-----PGDLRTHTQRSPQSLSAAIAAMQKF 71

  Fly    72 AGLNITGELDAETMKLMSLPRCGVRDRVGT---GDSRSKRYALQGSRWRVKNLTYKISKYPKRLK 133
            .||.:||:.|..||..|..|||||.|:.||   .:.|.||||:||.:|:...:|:.|..|..::.
Mouse    72 YGLQVTGKADLATMMAMRRPRCGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVG 136

  Fly   134 RVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVH--------IEIKFVESEHGDGDAFDGQGGTLAH 190
            .......|.:||.||...|.|.|.......:.        |.|.|.|..|||...|||:||.|||
Mouse   137 EYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAH 201

  Fly   191 AFF--PVFGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP 251
            |:|  |..|||.|||.||.||:.:.  .|.::|.||.||.||:|||.||:..||:|||||:..:.
Mouse   202 AYFPGPNIGGDTHFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDT 266

  Fly   252 V-FKLDEDDKAAIQSLYGRKTNQLRPTNV--YPATTQRPYSP--PKVP-LDDSICKDSKVDTLFN 310
            . |.|.:||:..||.|||.|:..  ||.:  .|.||.||..|  ||.| ...:|| |...||: .
Mouse   267 ENFVLPDDDRRGIQQLYGSKSGS--PTKMPPQPRTTSRPSVPDKPKNPAYGPNIC-DGNFDTV-A 327

  Fly   311 SAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQG 375
            ..:||.:.||...::::..:.|.:|||..|.:.|.|||.:|:.|:..|:||..||||.::|.:..
Mouse   328 MLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE 392

  Fly   376 RQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW 439
            ..::..|||.|.|...|:| |.:|||:.|..|||.|||:|:|::||:...| .|.:.|||.|..|
Mouse   393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEEFR-AVDSEYPKNIKVW 456

  Fly   440 EGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSSTGNI 503
            ||:|.:...:...::. :|||:||:||::|::.:..|:   |.:|:.....|.||   ||. |..
Mouse   457 EGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE---PGYPKSALRDWMGC---PSG-GRP 514

  Fly   504 VEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAMSQSKLTSSSAVST 568
            .||::.|                            .|.|:.||.|. |:||:        ||.:.
Mouse   515 DEGTEEE----------------------------TEVIIIEVDEE-GSGAV--------SAAAV 542

  Fly   569 VITTILMCLV 578
            |:..:|:.||
Mouse   543 VLPVLLLLLV 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 23/58 (40%)
Peptidase_M10 115..268 CDD:425668 67/165 (41%)
HX 298..493 CDD:238046 72/196 (37%)
Mmp14NP_032634.3 PG_binding_1 36..88 CDD:460223 23/56 (41%)
Cysteine switch. /evidence=ECO:0000250|UniProtKB:P03956 91..98 5/6 (83%)
Peptidase_M10 118..284 CDD:425668 67/165 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..316 16/37 (43%)
HX 316..508 CDD:238046 72/197 (37%)
Hemopexin 1 316..364 15/49 (31%)
Hemopexin 2 365..410 16/44 (36%)
Hemopexin 3 412..460 24/48 (50%)
Hemopexin 4 461..508 12/49 (24%)
DUF3377 <560..582 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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