DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp13

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_032633.1	Gene:	Mmp13 / 17386	MGIID:	1340026	Length:	472	Species:	Mus musculus

Alignment Length:	449	Identity:	170/449 - (37%)
Similarity:	228/449 - (50%)	Gaps:	48/449 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AEIYLSQFGYLPASARNPASSGLHDQRTWVSAIE---EFQSFAGLNITGELDAETMKLMSLPRCG 94
            ||.||..: |.||:.     :|:..:.|..|.::   |.|||.||.:||:||..|:.:|..||||
Mouse    40 AEHYLKSY-YHPATL-----AGILKKSTVTSTVDRLREMQSFFGLEVTGKLDDPTLDIMRKPRCG 98

  Fly    95 VRDRVGTGDSRSKRYAL--QGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFT 157
            |.| ||       .|.:  :..:|...||||:|..|...:...:|:....:||.|||:.|.|.||
Mouse    99 VPD-VG-------EYNVFPRTLKWSQTNLTYRIVNYTPDMSHSEVEKAFRKAFKVWSDVTPLNFT 155

  Fly   158 RKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNLFQ 220
            |...|...|.|.|...||||...|||..|.|||||  .|.:||||||||.|.|| .|.:|.|||.
Mouse   156 RIYDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT-SSSKGYNLFI 219

  Fly   221 VAAHEFGHSLGLSHSDQSSALMAPF--YRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPAT 283
            |||||.||||||.||....|||.|.  |.| :..|.|.:||...||.|||.......|
Mouse   220 VAAHELGHSLGLDHSKDPGALMFPIYTYTG-KSHFMLPDDDVQGIQFLYGPGDEDPNP------- 276

  Fly   284 TQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVE-EGYPQLISKGWPGL 347
             :.|.:|.|  .|.::..|:     ..|.:|||..||...:::|....|| |.:  |....||.|
Mouse   277 -KHPKTPEK--CDPALSLDA-----ITSLRGETMIFKDRFFWRLHPQQVEAELF--LTKSFWPEL 331

  Fly   348 PGNIDAAFTYKNGKTYF-FKGTQYWRYQGRQMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIY 410
            |.::|||:.:.:....| |:|.::|...|..:...||::||: ||......|.||:.:...||..
Mouse   332 PNHVDAAYEHPSRDLMFIFRGRKFWALNGYDILEGYPRKISDLGFPKEVKRLSAAVHFENTGKTL 396

  Fly   411 FFKGSKFWRFDPAKRPPVKASYPKPI-SNWEGVPNNLDAALKYTNGYTYFFKGDKYYRF 468
            ||..:..|.:|...:...| .||:.| ..:.|:.|.:||..: .|||.|||.|...:.:
Mouse   397 FFSENHVWSYDDVNQTMDK-DYPRLIEEEFPGIGNKVDAVYE-KNGYIYFFNGPIQFEY 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	21/57 (37%)
		Peptidase_M10	115..268	CDD:278824	78/156 (50%)
		ZnMc_MMP	115..268	CDD:239805	78/156 (50%)
		HX	298..493	CDD:238046	54/175 (31%)
Mmp13	NP_032633.1	PG_binding_1	33..92	CDD:279773	21/57 (37%)
		Cysteine switch. /evidence=ECO:0000250	95..102		6/7 (86%)
		Peptidase_M10	113..268	CDD:278824	78/156 (50%)
		ZnMc_MMP	113..268	CDD:239805	78/156 (50%)
		Interaction with TIMP2. /evidence=ECO:0000250	177..247		43/70 (61%)
		Interaction with collagen. /evidence=ECO:0000250	269..472		59/204 (29%)
		HX	282..472	CDD:238046	57/183 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920