Protein Alignment Mmp1 and Mmp12

DIOPT Version :10

• Sequence 1: NP_726473.2
• Gene: Mmp1 / 37949
• FlyBaseID: FBgn0035049
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_032631.3
• Gene: Mmp12 / 17381
• MGIID: 97005
• Length: 473
• Species: Mus musculus
• Alignment Length: 506
• Identity: 185/506 - (36%)
• Similarity: 255/506 - (50%)
• Gaps: 58/506 - (11%)

  Fly     4 CQSSVFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEF 68
            |.....:::  :|..::|..:||::.:..||.|||:| |.....|.|.:....::......::|.
Mouse    10 CTMKFLMMI--VFLQVSACGAAPMNDSEFAEWYLSRF-YDYGKDRIPMTKTKTNRNFLKEKLQEM 71

  Fly    69 QSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLK 133
            |.|.||..||:||..|:.:|.:|||||      .|.:..|...|.|||..:.|||:|..|...:|
Mouse    72 QQFFGLEATGQLDNSTLAIMHIPRCGV------PDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMK 130

  Fly   134 RVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVFG- 197
            |.|||....:||.|||:.|.|.|.:.......|.|.|....|||.:.|||:||||||||:|..|
Mouse   131 REDVDYIFQKAFQVWSDVTPLRFRKLHKDEADIMILFAFGAHGDFNYFDGKGGTLAHAFYPGPGI 195

  Fly   198 -GDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLDEDDK 260
             ||||||:||.|| .|.:|||||.||.||.||||||.||:...::|.|.||...| .|:|..||.
Mouse   196 QGDAHFDEAETWT-KSFQGTNLFLVAVHELGHSLGLQHSNNPKSIMYPTYRYLNPSTFRLSADDI 259

  Fly   261 AAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYY 325
            ..||||||        ..|.|.:..:|.|||......|:..|: |.|:     ||...|..|.::
Mouse   260 RNIQSLYG--------APVKPPSLTKPSSPPSTFCHQSLSFDA-VTTV-----GEKIFFFKDWFF 310

  Fly   326 --KLTTDSVEEGYPQL----ISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQGRQMDGVYP 383
              ||      .|.|..    ||..||.:|..|.||:..:: .:.:.||..:||.......:..||
Mouse   311 WWKL------PGSPATNITSISSIWPSIPSGIQAAYEIESRNQLFLFKDEKYWLINNLVPEPHYP 369

  Fly   384 KEI-SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNL 446
            :.| |.||:.....:|||:......|:|||....:||:| .::..:..:|||.|| ::.|:...:
Mouse   370 RSIYSLGFSASVKKVDAAVFDPLRQKVYFFVDKHYWRYD-VRQELMDPAYPKLISTHFPGIKPKI 433

  Fly   447 DAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPT----AHWWFGC 493
            ||.|.:...| |.|:| .|...:|         |.|.|.|    :..||||
Mouse   434 DAVLYFKRHY-YIFQG-AYQLEYD---------PLFRRVTKTLKSTSWFGC 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:460223	19/55 (35%)
		Peptidase_M10	115..268	CDD:425668	80/155 (52%)
		HX	298..493	CDD:238046	61/207 (29%)
Mmp12	NP_032631.3	PG_binding_1	37..91	CDD:460223	19/54 (35%)
		Cysteine switch. /evidence=ECO:0000250	94..101		5/12 (42%)
		Peptidase_M10	112..267	CDD:425668	80/155 (52%)
		HX	289..473	CDD:238046	61/207 (29%)
		Hemopexin 1	289..332		16/54 (30%)
		Hemopexin 2	333..379		14/45 (31%)
		Hemopexin 3	381..429		15/48 (31%)
		Hemopexin 4	430..473		15/53 (28%)