DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP21

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_671724.1 Gene:MMP21 / 118856 HGNCID:14357 Length:569 Species:Homo sapiens


Alignment Length:569 Identity:181/569 - (31%)
Similarity:248/569 - (43%) Gaps:130/569 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 QSAPVSTTTQAEIYLSQFGYLPA-SARNPASSGLHDQ---RTWVSAIEEFQSFAGLNITGELDAE 83
            |:.|::....|:.:||::|:... :|..|:..|..:.   .....|:..||....|..:|||||.
Human    43 QAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAA 107

  Fly    84 TMKLMSLPRCGVRDRVGTGDS---------------RSKRYALQGSR--WR-------------- 117
            |:..|:.|||||.|......|               ||.|..|..||  |:              
Human   108 TLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFS 172

  Fly   118 VKNLTYKI--SKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGP---VHIEIKFVESEH-G 176
            .:.|::::  .....:|...|....:..||.:|||.|.|.|....:.|   |.|::.|....| |
Human   173 KRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLG 237

  Fly   177 DGDAFDGQGGTLAHAFFPVFGGDAHFDDAELWT-IGSPRGTNLFQVAAHEFGHSLGLSHSDQSSA 240
            ...||||.|...|||:..   ||.||||.|.:| ..|..|.:|.:||.||.||.|||.|:.::.:
Human   238 CPRAFDGSGQEFAHAWRL---GDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGS 299

  Fly   241 LMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKV 305
            :|.|.|...||.|:||..|:.|||.|||.                              |:.| .
Human   300 IMQPNYIPQEPAFELDWSDRKAIQKLYGS------------------------------CEGS-F 333

  Fly   306 DTLFN------SAQGE------TYAFKGDKY--YKLTTDSVEEGYPQLISKGWPGLP-GNIDA-- 353
            ||.|:      :..||      ||.|:...|  |:...:....|.|..|..||||:| .||||  
Human   334 DTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFV 398

  Fly   354 -AFTYKNGKTYFFKGTQYWRY------------QGRQMDGVYPKEISEGFTGIPDHLDAAMVWGG 405
             .:|:|..:.|||:|.|||||            ||:.    |||.|||||.|||..||.|.....
Human   399 HIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS----YPKLISEGFPGIPSPLDTAFYDRR 459

  Fly   406 NGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVP---------NNLDAALKYTNGYT--YF 459
            ...|||||.|..:.|| ..|..|..||||.|:  |..|         .|:|:|. |:..|.  :|
Human   460 QKLIYFFKESLVFAFD-VNRNRVLNSYPKRIT--EVFPAVIPQNHPFRNIDSAY-YSYAYNSIFF 520

  Fly   460 FKGDKYYRFHDARFAVDSATPP----FPRP-TAHWWFGCKNTPSSTGNI 503
            |||:.|::..:.:....::..|    ||:. .:..||...:...||.|:
Human   521 FKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773 17/59 (29%)
Peptidase_M10 115..268 CDD:278824 61/175 (35%)
ZnMc_MMP 115..268 CDD:239805 61/175 (35%)
HX 298..493 CDD:238046 83/240 (35%)
MMP21NP_671724.1 PG_binding_1 48..112 CDD:279773 17/63 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..166 14/50 (28%)
Cysteine switch. /evidence=ECO:0000250 115..122 5/6 (83%)
Peptidase_M10 170..327 CDD:278824 59/159 (37%)
ZnMc_MMP 171..327 CDD:239805 59/158 (37%)
Hemopexin 1 330..389 17/59 (29%)
HX 350..536 CDD:238046 71/193 (37%)
Hemopexin 2 391..447 25/59 (42%)
Hemopexin 3 448..496 21/50 (42%)
Hemopexin 4 503..559 15/56 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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