DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and Mmp28

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001307229.1	Gene:	Mmp28 / 118453	MGIID:	2153062	Length:	520	Species:	Mus musculus

Alignment Length:	509	Identity:	180/509 - (35%)
Similarity:	260/509 - (51%)	Gaps:	70/509 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QAEIYLSQFGYL-PASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGV 95
            :||.:|.::||| ...::.|||:...      :||.|||..:.|.::|.||..|::.|:.|||||
Mouse    35 EAEAFLEKYGYLSEQGSKAPASAQFR------NAIREFQWISQLPLSGVLDQATLRQMTRPRCGV 93

  Fly    96 RD---------RVGT---GD----SRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRA 144
            .|         |:.|   |.    .|.||:|..|::|..::|:|::..:|:||....|...:..|
Mouse    94 ADTDSHATWTERISTLLAGHRAKMRRKKRFAKPGNKWYKQHLSYRLVNWPERLPEPAVRGAVRAA 158

  Fly   145 FAVWSEDTDLTF-TRKTSGPVHIEIKFVESEHGDG--DAFDGQGGTLAHAFFPVFGGDAHFDDAE 206
            |.:||..:.|.| ....:||..|.:.|.:.:|.||  :||||.||.|||||.| ..|:||||..|
Mouse   159 FQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLP-RRGEAHFDGDE 222

  Fly   207 LWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRK- 270
            .|::...||.|||.|.|||.||:|||:||....|||||:|:.......|..||..|:|||||:.
Mouse   223 RWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDVLAVQSLYGKPL 287

  Fly   271 ----TNQLRPTNVY-------PATTQ--RPYS-PPKVPLDDSICKDSKVDTLFNSAQGETYAFKG 321
                ..|| |..|:       |..:|  ||.: .||      .| .|..|.:....|...|.|||
Mouse   288 GRSVATQL-PGKVFTDFEAWDPHNSQSRRPETRGPK------YC-HSSFDAITVDGQWRLYVFKG 344

  Fly   322 DKYYKLTTD-SVEEGYPQLISKGWPGLPGNID-AAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPK 384
            ..::::|.| :|.|  |:.:.|.|||||..|: ||.:.::|..|||||.:.||:||.:....:.:
Mouse   345 SYFWEVTVDGNVSE--PRPLQKRWPGLPPGIEAAAVSLEDGDFYFFKGNRCWRFQGTKSVWGFAQ 407

  Fly   385 EISEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAA 449
            ....|  |:|.|.|||:.:....::..||||:::....... .|:..||:.:.:|.|||..:..|
Mouse   408 LCRAG--GLPRHPDAALFFPPLRRLVLFKGSRYYVLAQGGM-QVEPYYPRSLRDWAGVPEEVSGA 469

  Fly   450 LKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGCKNTPS 498
            |...:|...||:.|.|:....|:..|.|        :..|     |.||.|..|
Mouse   470 LPRPDGSIIFFRDDHYWHLDQAKLRVTS--------SGRWATELSWMGCWNANS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	19/56 (34%)
		Peptidase_M10	115..268	CDD:278824	68/155 (44%)
		ZnMc_MMP	115..268	CDD:239805	68/155 (44%)
		HX	298..493	CDD:238046	62/201 (31%)
Mmp28	NP_001307229.1	PG_binding_1	31..86	CDD:279773	19/56 (34%)
		Peptidase_M10	129..284	CDD:278824	68/155 (44%)
		ZnMc_MMP	129..284	CDD:239805	68/155 (44%)
		HX	321..510	CDD:238046	64/208 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880