DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp1 and Mmp10

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_598198.2	Gene:	Mmp10 / 117061	RGDID:	620192	Length:	476	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	174/450 - (38%)
Similarity:	236/450 - (52%)	Gaps:	42/450 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGS-RWRVKN 120
            |....|..|||.|.|.||.:||:||:.|:::|..|||||.| || |.|     ...|| :||..:
  Rat    56 DSSPVVKKIEEMQKFLGLEMTGKLDSNTVEMMHKPRCGVPD-VG-GFS-----TFPGSPKWRKNH 113

  Fly   121 LTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQG 185
            ::|:|..|...|.|..||:.|.||..||.|.|.|||:|.:.|...|.|.|...||||...|||.|
  Rat   114 ISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGVG 178

  Fly   186 GTLAHAF--FPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYR- 247
            .:||||:  .|.|.|||||||.|.|::| |.|||||.|||||.||||||.||:...:||.|.||
  Rat   179 QSLAHAYPPGPGFYGDAHFDDDEKWSLG-PSGTNLFLVAAHELGHSLGLFHSNNKESLMYPVYRF 242

  Fly   248 -GFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNS 311
             ..:...:|.:||...||||||.:.:........|:.:.:|.:|  |..|.::..|:     ...
  Rat   243 STSQANIRLSQDDIEGIQSLYGARPSSDATVVPVPSVSPKPETP--VKCDPALSFDA-----VTM 300

  Fly   312 AQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQG 375
            .:||...||...:::.|..:.|..: .|||..||.||..:|||:...| .:...|||:|:|..:|
  Rat   301 LRGEFLFFKDRHFWRRTQWNPEPEF-HLISAFWPSLPSGLDAAYEANNKDRVLIFKGSQFWAVRG 364

  Fly   376 RQMDGVYPKEI-SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-N 438
            .::...|||.| :.||......:|||:......|.|||.|.|:||||.. |..:...:|:.|: :
  Rat   365 NEVQAGYPKRIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDET-RQLMDKGFPRLITDD 428

  Fly   439 WEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHW-----WFGC 493
            :.|:...:||.| :..|:.|||:|...:.|           .|..|...|.     |..|
  Rat   429 FPGIEPQVDAVL-HAFGFFYFFRGSSQFEF-----------DPNARTVTHTLKSNSWLLC 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	14/30 (47%)
		Peptidase_M10	115..268	CDD:278824	79/156 (51%)
		ZnMc_MMP	115..268	CDD:239805	79/156 (51%)
		HX	298..493	CDD:238046	60/202 (30%)
Mmp10	NP_598198.2	PG_binding_1	33..87	CDD:396175	14/30 (47%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/7 (86%)
		Peptidase_M10	108..264	CDD:395334	79/156 (51%)
		HX	286..476	CDD:238046	63/210 (30%)
		Hemopexin 1	286..335		15/56 (27%)
		Hemopexin 2	336..382		17/45 (38%)
		Hemopexin 3	384..432		16/48 (33%)
		Hemopexin 4	433..476		13/54 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850