DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and MMP24

DIOPT Version :10

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_006681.1 Gene:MMP24 / 10893 HGNCID:7172 Length:645 Species:Homo sapiens


Alignment Length:609 Identity:216/609 - (35%)
Similarity:298/609 - (48%) Gaps:106/609 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 AAQSAPVSTTTQAEI------YLSQFGY-LPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITG 78
            ||.:..|:...:||.      :|..:|| ||..:|   :|.||..:...||:...|.|.|:.:||
Human    63 AAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSR---ASALHSAKALQSAVSTMQQFYGIPVTG 124

  Fly    79 ELDAETMKLMSLPRCGVRDRVG-TGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIG 142
            .||..|::.|..|||||.|... :...|:|||||.|.:||.|::||.|..|..::..:|....|.
Human   125 VLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIR 189

  Fly   143 RAFAVWSEDTDLTFTRKTSGPVHIEIK-----------FVESEHGDGDAFDGQGGTLAHAFF--P 194
            :||.||.:.|.|||...   |.| |||           |....|||...|||:||.||||:|  |
Human   190 QAFDVWQKVTPLTFEEV---PYH-EIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGP 250

  Fly   195 VFGGDAHFDDAELWTIGSPR--GTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLD 256
            ..|||.|||..|.||:|:..  |.:||.||.||.||:|||.||...||:|||||:..|. .|||.
Human   251 GIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLP 315

  Fly   257 EDDKAAIQSLYGRKTNQLRPTNVYPATT------------QRPYSPPKVPLDD---------SIC 300
            :||...||.:||.....|.||...|...            :|...||:.||.|         :||
Human   316 QDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNIC 380

  Fly   301 KDSKVDTLFNSA---QGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKT 362
                 |..||:.   :||.:.||...:::|..:.|:||||..|.:.|.|||..||||:...:|:.
Human   381 -----DGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRF 440

  Fly   363 YFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP-DHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRP 426
            .||||.:||.::...::..||..:.|..:.:| :.:|.|:.|...||.|||||.::||:...:| 
Human   441 VFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERR- 504

  Fly   427 PVKASYPKPISNWEGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWW 490
            .....|||||:.|:|:|.....|.....| ||||:||..|::|.:.:.:|:   |.:||.....|
Human   505 ATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVE---PGYPRNILRDW 566

  Fly   491 FGCKNTPSSTGNIVEGSDNEFEQHSMIPHADDGNGDDFDAAVGDHQSNDEPIVPEVAERTGNGAM 555
            .||..           .:.|..:...:|.      ||.|..|   ..||.|              
Human   567 MGCNQ-----------KEVERRKERRLPQ------DDVDIMV---TINDVP-------------- 597

  Fly   556 SQSKLTSSSAVSTVITTIL-MCLV 578
                 .|.:||:.||..|| :|::
Human   598 -----GSVNAVAVVIPCILSLCIL 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:460223 21/62 (34%)
Peptidase_M10 115..268 CDD:425668 76/168 (45%)
HX 298..493 CDD:238046 71/199 (36%)
MMP24NP_006681.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
PG_binding_1 82..134 CDD:460223 19/54 (35%)
Cysteine switch. /evidence=ECO:0000250 137..144 5/6 (83%)
Peptidase_M10 162..327 CDD:425668 76/168 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..380 13/56 (23%)
HX 377..569 CDD:238046 71/200 (36%)
Hemopexin 1 377..425 17/52 (33%)
Hemopexin 2 426..471 15/44 (34%)
Hemopexin 3 473..521 20/48 (42%)
Hemopexin 4 522..569 15/49 (31%)
DUF3377 575..645 CDD:463374 17/70 (24%)
PDZ-binding 643..645
Blue background indicates that the domain is not in the aligned region.

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