DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp1 and PRG4

DIOPT Version :9

Sequence 1:NP_726473.2 Gene:Mmp1 / 37949 FlyBaseID:FBgn0035049 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_005798.3 Gene:PRG4 / 10216 HGNCID:9364 Length:1404 Species:Homo sapiens


Alignment Length:299 Identity:78/299 - (26%)
Similarity:112/299 - (37%) Gaps:83/299 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 LRPTNVYPATTQRPYSPPKVP---------LDD--SICKDSKVDTLFNSAQGETYAFKGDKYYKL 327
            |||....|..|......|:||         |.|  :||....||.|.....|...||:|..::.|
Human  1109 LRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRNGTLVAFRGHYFWML 1173

  Fly   328 TTDSVEEGYPQLISKGWPGLPGNIDAAFTYKN--GKTYFFKGTQYWRYQGRQMDGVYPKEISEGF 390
            :..| .....:.|::.| |:|..||..||..|  |||:|||.:||||:.....|..|||.|.:||
Human  1174 SPFS-PPSPARRITEVW-GIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGF 1236

  Fly   391 TGIPDHLDAAMV------WGGNGKIYFFK-GSKFWRF---------DPAKRP------------- 426
            .|:...:.||:.      |..:  :|||| |....::         .|.:||             
Human  1237 GGLTGQIVAALSTAKYKNWPES--VYFFKRGGSIQQYIYKQEPVQKCPGRRPALNYPVYGETTQV 1299

  Fly   427 ----------------------PVKASYP---------KPISNWEGVPNNLDAALKYTN-----G 455
                                  |.:.:|.         |....|.|:||.:.:|:...|     |
Human  1300 RRRRFERAIGPSQTHTIRIQYSPARLAYQDKGVLHNEVKVSILWRGLPNVVTSAISLPNIRKPDG 1364

  Fly   456 YTYF-FKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGC 493
            |.|: |..|:||..........:.|....:..:..|:.|
Human  1365 YDYYAFSKDQYYNIDVPSRTARAITTRSGQTLSKVWYNC 1403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp1NP_726473.2 PG_binding_1 32..88 CDD:279773
Peptidase_M10 115..268 CDD:278824
ZnMc_MMP 115..268 CDD:239805
HX 298..493 CDD:238046 67/262 (26%)
PRG4NP_005798.3 SO 26..68 CDD:197571
SO 66..108 CDD:197571
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..966
SSL_OB 304..>441 CDD:332684
59 X 8 AA repeats of K-X-P-X-P-T-T-X 348..855
Atrophin-1 <374..839 CDD:331285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 992..1104
HX 1143..1403 CDD:238046 67/263 (25%)
Hemopexin 1 1148..1191 11/44 (25%)
Hemopexin 2 1192..1239 23/46 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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