DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp8

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_002944454.2	Gene:	mmp8 / 100494588	XenbaseID:	XB-GENE-952402	Length:	455	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	171/464 - (36%)
Similarity:	228/464 - (49%)	Gaps:	52/464 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MAAAQSAPVSTTTQAEIYLSQFG--YLPASAR----NPASSGLHDQRTWVSAIEEFQSFAGLNIT 77
            :|.....|....|..|.:...|.  ||....|    ..:.|.|.|:      |::.|:|.||.:|
Frog    11 IACTMGFPAGILTDTEKHNEAFAKEYLKKFYRFEGEGTSRSALLDK------IQKMQNFFGLEVT 69

  Fly    78 GELDAETMKLMSLPRCGVRD--RVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAE 140
            ..|:.||:.:|..|||||.|  |..|....:.        |:.|:|||:|..|...:.|.|||..
Frog    70 ARLNEETIDVMKQPRCGVPDIARFSTFSGNAV--------WKKKDLTYRILNYTPDMTRNDVDRA 126

  Fly   141 IGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VFGGDAHFD 203
            |.:||.|||:...|||||.......||:.|...:|.|...|||..|.|||||.|  ..|||.|||
Frog   127 IEKAFKVWSDVVPLTFTRIYDRVSDIEMLFAYRDHKDSLPFDGPSGILAHAFAPGDNIGGDVHFD 191

  Fly   204 DAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEP-VFKLDEDDKAAIQSLY 267
            :.|.||.|| .|||||.|||||.||||||.||:..:|||.|.|....| .|:|.:||...|.|||
Frog   192 EDEKWTSGS-AGTNLFLVAAHELGHSLGLDHSNDPNALMYPTYHYINPNTFQLPQDDINGIHSLY 255

  Fly   268 GRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSV 332
            |.|.|.:.|.               :...:.|..|: |.||    :|:...||...:::.|....
Frog   256 GTKENPIIPI---------------INCQEQISFDA-VTTL----RGDILFFKNRSFWRKTAGKS 300

  Fly   333 EEGYPQLISKGWPGLPGNIDAAF-TYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISE-GFTGIPD 395
            |....: ||..||.||.:.|||: ..|..:...||||:||..:|..:...:||.|.| ||.....
Frog   301 EIEQHE-ISSFWPSLPADFDAAYENQKKDQVLLFKGTKYWVLRGYTIQEGFPKNIYELGFPLTVT 364

  Fly   396 HLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPIS-NWEGVPNNLDAALKYTNGYTYF 459
            .:|||:.....|:.|||...::|.::.......|.| |:.|| .:.||.|.::||.: :||..|.
Frog   365 QIDAAVHDDETGRTYFFINDRYWSYNEETSQMDKES-PQRISKGFPGVGNKVEAAFR-SNGMLYL 427

  Fly   460 FKGDKYYRF 468
            |.|::.|.|
Frog   428 FSGNQQYEF 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	17/61 (28%)
		Peptidase_M10	115..268	CDD:278824	79/155 (51%)
		ZnMc_MMP	115..268	CDD:239805	79/155 (51%)
		HX	298..493	CDD:238046	58/174 (33%)
mmp8	XP_002944454.2	PG_binding_1	33..80	CDD:279773	15/52 (29%)
		Peptidase_M10	102..256	CDD:278824	79/154 (51%)
		ZnMc_MMP	102..256	CDD:239805	79/154 (51%)
		HX	271..455	CDD:238046	58/174 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000127
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10201
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110