DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp1 and mmp25

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_031749610.1	Gene:	mmp25 / 100379875	XenbaseID:	XB-GENE-5944489	Length:	545	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	197/506 - (38%)
Similarity:	275/506 - (54%)	Gaps:	59/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YLSQFGYLPA----SARNPASSGLHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVR 96
            :|:::||||.    |||.....||.:      |::..|..|||..|||||..|:::|:.|||.:.
Frog    29 WLTRYGYLPPPDPFSARQQTLEGLRE------AVKAMQRVAGLPETGELDDATVRMMNKPRCSLP 87

  Fly    97 DRVGTGDSRS---KRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAE-IGRAFAVWSEDTDLTFT 157
            |.:...:.||   |||||.||.|..|.||:::...|..:.: ||... ||.|.||||::|.|.|
Frog    88 DIIMRPEGRSRRNKRYALSGSVWDKKLLTWRLENSPNTMSQ-DVSRTLIGTALAVWSKETQLQF- 150

  Fly   158 RKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVFG---GDAHFDDAELWTIGSPRGTNLF 219
            |:|.....|.::||...||||..||||||||.|||||..|   |:.|.|..|.|:..:..||:||
Frog   151 RETREQPDIRVEFVTGSHGDGYPFDGQGGTLGHAFFPGVGERAGETHMDADESWSYNTEEGTDLF 215

  Fly   220 QVAAHEFGHSLGLSHSDQSSALMAPFYRGF--EPV-FKLDEDDKAAIQSLYGRKTNQLRPTNVYP 281
            .||.|||||||||.||...:::|.|:|:|.  :|. ::|..||...||:|||:..:..||    |
Frog   216 AVAVHEFGHSLGLYHSSSENSIMKPYYQGTVGDPSRYRLPPDDVDGIQTLYGQPDSGHRP----P 276

  Fly   282 ATTQR----PYSP---PKVPLDDSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQL 339
            .|..|    |..|   |::|..|. | .:..|.:.| .:||.:.||...::::.:..      ||
Frog   277 VTPTRRALPPRGPSPGPRLPFPDR-C-STNFDAIAN-IRGEAFFFKNRYFWRVQSSR------QL 332

  Fly   340 IS-------KGWPGLPGN---IDAAFTYKN-GKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGI 393
            :|       :.|.|||.:   :||.:...| .|..|..||.||.::...::..||:.::: |...
Frog   333 VSLNPAHLNRFWLGLPPDLPKLDAVYERTNDSKIVFISGTSYWVFKDTLVEPGYPRPLAD-FGLN 396

  Fly   394 PDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTY 458
            .|.:|||.||..|||.|||:.:.||||| .||..:.:.|||..|.|:|||.|:|..:.:.||.||
Frog   397 TDGVDAAFVWKHNGKTYFFRKNLFWRFD-EKRGQMDSGYPKDSSLWQGVPPNIDDIISWENGDTY 460

  Fly   459 FFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCK-NTPSSTGNIVEGSD 508
            ||||.:|::|.......|   |.:||.||..|..|. ..|:...:..||.|
Frog   461 FFKGTQYWKFQGGNVEAD---PGYPRSTALNWMYCPLEGPAVPTDAPEGRD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	21/55 (38%)
		Peptidase_M10	115..268	CDD:278824	73/159 (46%)
		ZnMc_MMP	115..268	CDD:239805	73/159 (46%)
		HX	298..493	CDD:238046	72/205 (35%)
mmp25	XP_031749610.1	PG_binding_1	29..79	CDD:396175	21/55 (38%)
		ZnMc_MMP	110..267	CDD:239805	73/158 (46%)
		HX	298..492	CDD:238046	73/207 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47536
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950