DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp25b

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_002663942.1	Gene:	mmp25b / 100333601	ZFINID:	ZDB-GENE-100308-4	Length:	573	Species:	Danio rerio

Alignment Length:	529	Identity:	197/529 - (37%)
Similarity:	271/529 - (51%)	Gaps:	55/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CQSSVFIVVGTLFSIMAAAQSAPVSTTTQAEI-YLSQFGYLPASARNPASSGLHDQRTWVSAIEE 67
            |...||         .:|..||||.......: :||::||||  ..:|.:..|..:.....||.|
Zfish    14 CPMLVF---------FSAVHSAPVKDQYSRGVDWLSRYGYLP--PLDPRTGQLQSKDGIERAIRE 67

  Fly    68 FQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGDS----RSKRYALQGSRWRVKNLTYKISKY 128
            .|.||||..||:||::|:.||:.|||.:.|.:|..|.    |.||||..|.||...::|:.:..|
Zfish    68 MQRFAGLKETGKLDSDTLTLMNTPRCSLPDIIGIEDKLKKRRRKRYATTGLRWTKSDITWSVQNY 132

  Fly   129 P---KRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGP---VHIEIKFVESEHGDGDAFDGQGGT 187
            |   |||....||..|..|...||:.|:|.|...:|..   ..|.|.|..|.|.||..|||:|||
Zfish   133 PSVHKRLTPTQVDPIISYALKAWSDVTNLNFYGASSSEKDRADIRISFARSLHDDGYPFDGKGGT 197

  Fly   188 LAHAFFP---VFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGF 249
            |||||||   ...||.||||.|:||.....||:||.||.|||||:||||||..|.::|.|:|:|.
Zfish   198 LAHAFFPGESDVAGDTHFDDDEIWTYLDESGTDLFAVAVHEFGHALGLSHSSSSPSIMKPYYQGS 262

  Fly   250 ---EPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSP---PKVPL--DDSI---CKDS 303
               ...:.|.:||:.|||||||||.:...|:...| |:..|..|   ||.|:  |.||   | :.
Zfish   263 VGDVGSYILPDDDREAIQSLYGRKISSPTPSPNKP-TSHLPKPPATYPKGPVKPDPSIQNRC-EG 325

  Fly   304 KVDTLFNSAQGETYAFKGDKYYKL-TTDSVEEGYPQLISKGWPGLP---GNIDAAFTYK-NGKTY 363
            ..|.:.| .:||.:.|||..:::: .|.|:....|..|...|.|||   ..:||.:..| :....
Zfish   326 GFDAVAN-LRGEVFFFKGPYFWRIQRTGSLVSFQPAHIKNFWMGLPPTTNKVDAVYERKVDNAII 389

  Fly   364 FFKGTQYWRYQGRQMDGVYPKEISEGFTGIPD-----HLDAAMVWGGNGKIYFFKGSKFWRFDPA 423
            ||.|:|||.::..::...||:.:|:......|     .:|||.:|..|||.|.|.|.:||||...
Zfish   390 FFIGSQYWVFKNTEVLPGYPRPLSDWGMITQDGRKVMRVDAAFIWAHNGKTYIFSGGEFWRFSEG 454

  Fly   424 KRPPVK---ASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRP 485
            :...::   ..||:..:.|:|.|:|.|..:.:..|..||||.:.|:...:......|.|   .:.
Zfish   455 RETELRGPDTGYPRNTNLWKGAPSNPDDVITWGQGDAYFFKDNSYWVLKNGEMDQTSVT---KKS 516

  Fly   486 TAHWWFGCK 494
            ||..|..|:
Zfish   517 TAVDWMMCQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	21/56 (38%)
		Peptidase_M10	115..268	CDD:278824	77/164 (47%)
		ZnMc_MMP	115..268	CDD:239805	77/164 (47%)
		HX	298..493	CDD:238046	63/210 (30%)
mmp25b	XP_002663942.1	PG_binding_1	38..88	CDD:279773	21/51 (41%)
		Peptidase_M10	119..284	CDD:278824	77/164 (47%)
		ZnMc_MMP	119..284	CDD:239805	77/164 (47%)
		HX	321..524	CDD:238046	61/207 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26047
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820