DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp1 and mmp17b

DIOPT Version :9

Sequence 1:	NP_726473.2	Gene:	Mmp1 / 37949	FlyBaseID:	FBgn0035049	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001352431.1	Gene:	mmp17b / 100322027	ZFINID:	ZDB-GENE-081107-17	Length:	613	Species:	Danio rerio

Alignment Length:	544	Identity:	153/544 - (28%)
Similarity:	237/544 - (43%)	Gaps:	98/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MAAAQSAPVSTTTQAEI-----YLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITG 78
            |..:...|.:..|:.|.     :|:::||||..  :|::..|........|:::.||||||:.||
Zfish    36 MVTSTILPTAIPTEDESGKLVDWLTKYGYLPPP--DPSTGQLQAWTAVTQAVKKMQSFAGLDETG 98

  Fly    79 ELDAETMKLMSLPRCGVRD---------RVGTGDSRSKRYALQGSRWRVKNLTYKISKYP--KRL 132
            .||.||::||..|||.:.|         .....|.:::|.....|.|..:|:.:::..||  .:|
Zfish    99 ILDEETLQLMQTPRCSLPDDDDDDQTIHSAQHADPQNQRMKRAVSTWTRRNINWRLRSYPVSSKL 163

  Fly   133 KRVDVDAEIGRAFAVWSEDTDLTFTRKTSGP--VHIEIKFVESEHGDGDAFDGQGGTLAHAFFPV 195
            .|..:.:.:..|..||::.|.|.| .:..||  ..::|.|:...||||..|||.||::.|||||.
Zfish   164 SRETIRSLVFYALRVWADPTLLEF-HEVRGPEGADLQIDFLHGPHGDGYPFDGAGGSVGHAFFPS 227

  Fly   196 ---FGGDAHFDDAELWTIGSP--RGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRG--FEPV- 252
               ..|..|.|..|.|....|  .||:||.|..||.||:|||:||....::|.|:|:|  .:|:
Zfish   228 DPNRAGGVHLDAEEDWAFRQPATEGTDLFTVLVHELGHALGLTHSSARRSVMRPYYQGPLGDPLH 292

  Fly   253 FKLDEDDKAAIQSLYGRKTNQLRPTNVYPAT-TQ-------------RPYSPPKVPLDDSICKDS 303
            |.|...|...|.:|||::.|.:......|.| ||             ..:|.|          ||
Zfish   293 FSLGYQDLQHITALYGQRGNDIPTETPLPVTETQLRHRHHRLTHMYRHAHSHP----------DS 347

  Fly   304 KVD---TLFNSA---QGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKT 362
            .||   |.|::.   :||.:.|||...::::...:.......|.:.|..||.::..........|
Zfish   348 SVDRCNTSFDAVAKIRGEIFFFKGQSMWRISRGGLVSVRVVPIQRLWSALPPSLPPLRAVLERHT 412

  Fly   363 ----YFFKGTQYWRYQGRQMDGVYPKEI------SEGFTGIPDHLDAAMVWGGNGKIYFFKGSKF 417
                .|..|:|.|.::...:...:|:.:      ..||.|:.......:|||...:....:.:|.
Zfish   413 DHAIIFISGSQVWLFKDLSLQDGFPQPLPTLADSDGGFEGLRWDPTQGVVWGSIREEEQNEDNKV 477

  Fly   418 WRFDPAKRPPVKASYPKPISNWEGVPNNL---DAALKYTN----GYTYFFKGDKYYRF-HDARFA 474
            ||                 ...||..|.:   :...:.||    |.||.|||:.|::| |.....
Zfish   478 WR-----------------ELIEGGVNGIIMENDHQRETNRGFKGSTYIFKGNSYWKFTHPGSAP 525

  Fly   475 VDSATPPFPRPTAHWWFGCKNTPS 498
            |:.    :||.:|..|..|....|
Zfish   526 VEG----YPRLSASDWLDCPQDSS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp1	NP_726473.2	PG_binding_1	32..88	CDD:279773	21/60 (35%)
		Peptidase_M10	115..268	CDD:278824	60/164 (37%)
		ZnMc_MMP	115..268	CDD:239805	60/164 (37%)
		HX	298..493	CDD:238046	49/218 (22%)
mmp17b	NP_001352431.1	PG_binding_1	55..108	CDD:307564	20/54 (37%)
		ZnMc_MMP	145..308	CDD:239805	60/163 (37%)
		HX	350..540	CDD:238046	46/210 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12370
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920