Protein Alignment CG4806 and TIA1

DIOPT Version :10

• Sequence 1: NP_611955.2
• Gene: CG4806 / 37948
• FlyBaseID: FBgn0260456
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_071505.2
• Gene: TIA1 / 7072
• HGNCID: 11802
• Length: 386
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 85/451 - (18%)
• Similarity: 143/451 - (31%)
• Gaps: 167/451 - (37%)

  Fly    50 LIVRNISYKSTEDSLREHFGQWGTLEDVHILKRGDGKLVGCAFVQYETINQATKAILNSNGKELL 114
            |.|.|:|...||..:.:.|.|.|..::..::....|....| ||::.....|..|:...||::::
Human     9 LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYC-FVEFHEHRHAAAALAAMNGRKIM 72

  Fly   115 GRKVFVDWALGKDEYVSKNPKDEEPDEKKPKVEVKEENGDEKEVKEESDAEVGKEDESSGEDSDA 179
            |::|.|:||             ..|..:|               |:.|.:.|.....|
Human    73 GKEVKVNWA-------------TTPSSQK---------------KDTSSSTVVSTQRS------- 102

  Fly   180 ESGEDEEDSGESEDEENDEDHKENKDELKSKLDIKNVKREKQISNDVQEGCTVFIKNVPFDAEDA 244
                              :||..                             ||:.::..:....
Human   103 ------------------QDHFH-----------------------------VFVGDLSPEITTE 120

  Fly   245 DLRKACRKFGLVSYAIINRQAVSGHSKGTAFVKFKAKESADLCLQ-------AGTEFKLMDEVLD 302
            |::.|...||.:|.|.:.:...:|.|||..||.|..|..|:..:|       .|.:.:.......
Human   121 DIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRK 185

  Fly   303 PHPALSREEMKSKQSQENKKDDAKDSRNLYLAREGLIMAGAKAADGVSASDMAKRHELEQVKTQV 367
            |....|..|..:||...::..:.....|..:...|:       ..|::          ||:..|
Human   186 PPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGV-------TSGLT----------EQLMRQ- 232

  Fly   368 LKNLNRFVSRNRLSIHNLPQNYDNEKLKQMALTYTGFRPHECRVMREHKVTPEHPQGKSKGFGFL 432
                                            |::.|.    ::| |.:|.|:      ||:.|:
Human   233 --------------------------------TFSPFG----QIM-EIRVFPD------KGYSFV 254

  Fly   433 SFDTHQRALAALRKLNNNPNIFGTQSRPIVAFSIEDRAVHKIKEKRTERSKQNNPTYQNKQ 493
            .|::|:.|..|:..:|      ||        :||...|.....|.|  ....||..|..|
Human   255 RFNSHESAAHAIVSVN------GT--------TIEGHVVKCYWGKET--LDMINPVQQQNQ 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4806	NP_611955.2	RRM2_RBM28_like	49..124	CDD:409848	21/73 (29%)
		RRM3_Nop4p	229..312	CDD:410077	21/89 (24%)
		RRM4_RBM28_like	379..468	CDD:409850	17/88 (19%)
		PTZ00121	<473..>622	CDD:173412	6/21 (29%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	20/72 (28%)
		RRM2_TIA1	104..181	CDD:410030	21/105 (20%)
		RRM3_TIAR	214..286	CDD:241064	24/146 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..386