DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4806 and bru1

DIOPT Version :9

Sequence 1:	NP_611955.2	Gene:	CG4806 / 37948	FlyBaseID:	FBgn0260456	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	98/504 - (19%)
Similarity:	171/504 - (33%)	Gaps:	145/504 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELKKMKSLKDDAAESQSQPETGVRKRRNPFNTQRLKEEKERRQKKRARLIVRNISYKSTEDSLRE 66
            :|.::.:|:|.....|:|.|...::.......||.:|.:..|:::|.|...|.....|..|:
  Fly   157 QLSQLAALQDHHDLLQTQQELFHKQLATMQEYQRERERERERERERERERERERDRSSFIDN--- 218

  Fly    67 HFGQWGTLEDVHILKRGDGKLVGCAFVQYETINQATKAILNS------NGKELLGRKVFVDWALG 125
              ..:.:..:..|..|..      ||...:..:.||.::.||      |...||
  Fly   219 --SDYDSQTEFKICLRDS------AFGMSDKSSSATNSLPNSPIHSNNNNPSLL----------- 264

  Fly   126 KDEYVSKNPKDEEPDEKKPKVEVKEENGDEKEVKEESDAEVGKEDES---SGEDSDA--ESGEDE 185
                                   ...|.:.......:...||..:.:   .|.:|:|  ..|.:.
  Fly   265 -----------------------NNNNNNSNGTSSNNSLNVGNNNSNPSLGGSNSNALVSVGSNG 306

  Fly   186 EDSGESEDEENDEDHKENK-------DELKSKLDIKNVKR--EKQISNDVQEGCTVFIKNVPFDA 241
            ..|.......|:.....|:       |:...:||......  ||:...|   ...:|:..||...
  Fly   307 IMSAAGLVNNNNNPCSANRNVVAMVDDDACFRLDTDATVTYGEKEPDPD---NIKMFVGQVPKSM 368

  Fly   242 EDADLRKACRKFGLVSYAIINRQAVSGHSKGTAFVKFKAKESADLCLQAGTEFKLMDEVLDPHPA 306
            :::.||:...::|.|....:.|...:|.|||..||.|..:.:|.....|....|.::.:.  ||.
  Fly   369 DESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDALHNVKTLNGMY--HPI 431

  Fly   307 LSREEMKSKQSQENKKDDAKDSRNLYLAREGLIMAGAKAADGVSASDMAKRHELEQVKTQVLKNL 371
                :||...| ||:.:     |.|::   |::.                            |.|
  Fly   432 ----QMKPADS-ENRNE-----RKLFV---GMLN----------------------------KKL 455

  Fly   372 NRFVSRNRLSIHNLPQNYDNEKLKQMALTYTGFRPHECRVMREHKVTPEHPQGKSKGFGFLSFDT 436
            |....|....:|...:                    ||.|:|:.       .|:|||..|::|.|
  Fly   456 NENDVRKLFEVHGAIE--------------------ECTVLRDQ-------NGQSKGCAFVTFAT 493

  Fly   437 HQRALAALR-KLNNNPNIFGTQSRPIVAFSIEDRAVHKIKEKRTERSKQ 484
            ...|::|:: .|:.|..:.|..|..:|.|:...      |||..::.:|
  Fly   494 KHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQ------KEKEQKKIQQ 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4806	NP_611955.2	RRM	<2..>154	CDD:223796	27/157 (17%)
		RRM_SF	49..124	CDD:302621	15/80 (19%)
		RRM3_RBM28_like	230..306	CDD:240861	19/75 (25%)
		RRM4_RBM28_like	379..468	CDD:240862	20/89 (22%)
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	22/86 (26%)
		ELAV_HUD_SF	359..808	CDD:273741	56/254 (22%)
		RRM2_Bruno_like	443..524	CDD:241080	27/143 (19%)
		RRM3_Bruno_like	722..800	CDD:241084
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030