DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4806 and Rbm28

DIOPT Version :9

Sequence 1:	NP_611955.2	Gene:	CG4806 / 37948	FlyBaseID:	FBgn0260456	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_006236252.1	Gene:	Rbm28 / 312182	RGDID:	1311336	Length:	753	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	249/720 - (34%)
Similarity:	364/720 - (50%)	Gaps:	119/720 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KSLKDDAAESQSQPETGVRKRRNPFNTQRLKEEKERRQK---KRARLIVRNISYKSTEDSLREHF 68
            |.||:.:.|:          |:|..:....||.|.::.|   |:||||:||:|:|.:||.|:..|
  Rat    80 KKLKNKSKET----------RKNENSESPKKEPKHKKAKVADKKARLIIRNLSFKCSEDDLKSVF 134

  Fly    69 GQWGTLEDVHILKRGDGKLVGCAFVQYETINQATKAILNSNGKELLGRKVFVDWALGKDEY---- 129
            ..:||:.:|:|.::.|||:.|.||:|::.:.:|.||:..:|.||:.||.|.||||:.||:|
  Rat   135 THYGTVLEVNIPRKPDGKMRGFAFIQFKNLLEAGKALKGANMKEIKGRTVAVDWAVAKDKYKDAQ 199

  Fly   130 --------VSKNPKDEEPDEKKPKVEVKEENGDEKEVKEESDAEVGKEDES-------------- 172
                    .|...|.:|..:|..:||.:.|:.|:....||.|.....||||
  Rat   200 HTSVSGGKKSSERKPKESSKKSCRVEEQVEDDDDDGEDEEDDDTQDDEDESRDSTVASPVSVRKR 264

  Fly   173 --------------SGEDSDAESGEDEEDSGESEDEENDEDHKENKDELKSKLDIKNVKREKQIS 223
                          :.:|||.|.|......|.:..|.:.|: .|::|...||      |:::::.
  Rat   265 AVKRAAPEESTEEDTYDDSDLEEGSSSYGDGTAHSESSTEE-LEDEDVPVSK------KKKRKLP 322

  Fly   224 NDVQEGCTVFIKNVPFDAEDADLRKACRKFGLVSYAIINRQAVSGHSKGTAFVKFKAKESADLCL 288
            :||.||.||||:|:.||:|:..|.:..::||.:.|..|.....:.||||.||.:|..:|:|..||
  Rat   323 SDVTEGKTVFIRNLSFDSEEEALGEVLQQFGDLKYVRIVLHPDTEHSKGCAFAQFVTQEAAQKCL 387

  Fly   289 QA------GTEFKLMDEVLDPHPALSREEMKSKQSQENKKDDAKDSRNLYLAREGLIMAGAKAAD 347
            .|      |...||....|....|::|:|....|:::.||...  :|||||||||||.||.|||:
  Rat   388 AAASPETEGGGLKLDGRQLKVDLAVTRDEAAKLQTKKVKKPTG--TRNLYLAREGLIRAGTKAAE 450

  Fly   348 GVSASDMAKRHELEQVKTQVLKNLNRFVSRNRLSIHNLPQNYDNEKLKQMALTYT----GFRPHE 408
            ||||:|||||...|.:|.|.|||.|.|||:.||.:||||::.|:::|:::.|..|    |.|..|
  Rat   451 GVSAADMAKRERFELLKHQKLKNQNIFVSQTRLCLHNLPKSVDDKQLRKLLLQATGGEKGVRIKE 515

  Fly   409 CRVMREHKVTPEHPQGKSKGFGFLSFDTHQRALAALRKLNNNPNIFGTQSRPIVAFSIEDRAVHK 473
            |||||:.|......:|:|.|:.|:.|..|:.||.|||..||||..||.|.||||.||:|||...|
  Rat   516 CRVMRDLKAVHGKMKGQSLGYAFVEFQKHEHALRALRHFNNNPETFGPQKRPIVEFSLEDRRKLK 580

  Fly   474 IKEKRTERSKQ---NNPTYQNKQQERKER---RQQK--RNGQETKTPVPQADNKSKLQKHIKKLE 530
            :||.|.:||.|   :.|.....|:|:||:   :|||  :.|...::..|....|.:....
  Rat   581 VKELRIQRSLQKMGSKPVTSKPQKEQKEQGKDKQQKAAQGGTRDQSKAPGEQGKGRCTSW----- 640

  Fly   531 ASRAAKAEGKVAEKKQLSDVQGDFVGTAAK----------PGTSLKMRSKKKIVEQAKEHLKKVK 585
            .....|||   .|:.:|.|      ||..:          |...|:.|.|.|.:...|   .|.:
  Rat   641 TGFQTKAE---VEQVELPD------GTRRRKVLALPSHRGPKVRLRDRGKVKSLPSKK---PKPQ 693

  Fly   586 TEKRKQKNKKIRESHLAERKANNRPKQGRKKETDDLRPLINKYKNMISGNQGGGGVTGGKIKKPK 650
            ..:||||.::...|..|.:|     |....|.......|:.:||..:.|...|..:.       |
  Rat   694 MGQRKQKKQQSASSLQAPKK-----KAKESKAEAHFNRLVEQYKQKLLGPSKGASLV-------K 746

  Fly   651 RTKWY 655
            |:||:
  Rat   747 RSKWF 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4806	NP_611955.2	RRM	<2..>154	CDD:223796	57/161 (35%)
		RRM_SF	49..124	CDD:302621	34/74 (46%)
		RRM3_RBM28_like	230..306	CDD:240861	29/81 (36%)
		RRM4_RBM28_like	379..468	CDD:240862	43/92 (47%)
Rbm28	XP_006236252.1	RRM1_RBM28_like	5..78	CDD:240859
		ELAV_HUD_SF	6..408	CDD:273741	111/344 (32%)
		RRM2_RBM28_like	115..190	CDD:240860	34/74 (46%)
		PABP-1234	322..709	CDD:130689	158/405 (39%)
		RRM3_RBM28_like	329..411	CDD:240861	29/81 (36%)
		RRM4_RBM28_like	481..575	CDD:240862	43/93 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351021
Domainoid	1	1.000	77	1.000	Domainoid score	I8712
eggNOG	1	0.900	-	-		E1_KOG0127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2308
OMA	1	1.010	-	-		QHG55464
OrthoDB	1	1.010	-	-		D1181291at2759
OrthoFinder	1	1.000	-	-		FOG0003903
OrthoInspector	1	1.000	-	-		oto96798
orthoMCL	1	0.900	-	-		OOG6_102701
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2687
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810