DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4806 and rbm28

DIOPT Version :9

Sequence 1:	NP_611955.2	Gene:	CG4806 / 37948	FlyBaseID:	FBgn0260456	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001123392.1	Gene:	rbm28 / 100170156	XenbaseID:	XB-GENE-919947	Length:	828	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	243/786 - (30%)
Similarity:	388/786 - (49%)	Gaps:	150/786 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKKMKSLKDDAAESQSQPETGVRKRR------NPFNTQRLKEEKERR-QKKRARLIVRNISYKST 60
            :|::|..:....|.|...:..|.|.:      :..|.:.:|:.|:.| .:|:||||:||:|::.:
Frog    62 MKEIKEYEGRKIEVQVAKKKQVEKNKKAKCEESNENAKEVKKPKDARGAQKKARLIIRNLSFQCS 126

  Fly    61 EDSLREHFGQWGTLEDVHILKRGDGKLVGCAFVQYETINQATKAILNSNGKELLGRKVFVDWALG 125
            |:.|:|||..:|.:.:::|.|:.|||:.|.||||::.:.:|:||:..:|.|.:.||.|.||||:.
Frog   127 EEDLKEHFSNFGYVLEINIPKKSDGKMRGFAFVQFKNMLEASKALKGTNMKSIKGRTVAVDWAVA 191

  Fly   126 KDEYVS--------KNP---------KDEEPDEK---------------------------KPKV 146
            ||:|.:        ||.         |::|.|::                           |.|:
Frog   192 KDKYTATQETASAVKNESSKELDTAHKEDEEDKEGEGSLEEEESMETEEESEQTSERKQATKQKM 256

  Fly   147 EVKEENGDEKEVKEESDAEVGKEDESSGEDSDAESGEDEE-----------DSGESEDEENDEDH 200
            .:||.|....|.:|:.|.:.|  |...|:|.|.:.|.|.:           ||.:..|.|:|.|.
Frog   257 PMKESNVSSSEGEEDDDDDDG--DGGDGKDDDDDDGGDNDEIDEEKSDMSTDSEQDSDMEDDFDS 319

  Fly   201 KENKDELKSKLDIKNVKREKQISNDVQEGCTVFIKNVPFDAEDADLRKACRKFGLVSYAIINRQA 265
            ::::.|::.|...|..|.:.|:.:||.||.|:||:|:.|::|:.||.:...:||.:.|..|....
Frog   320 EDSEAEMQKKGKSKEKKPKIQLPSDVNEGRTLFIRNLSFNSEEEDLEEILLRFGNIKYVRIVLHP 384

  Fly   266 VSGHSKGTAFVKFKAKESADLCLQAGTE------FKLMDEVLDPHPALSREEMKSKQSQENKKDD 324
            |:.||||.|||::..|::|:.||.|..:      .||....|..:.|:||||  :.:.:|||...
Frog   385 VTEHSKGCAFVQYVEKQAAERCLAAANDQSENGGLKLDGRKLLVNLAVSREE--AGKLRENKVKK 447

  Fly   325 AKDSRNLYLAREGLIMAGAKAADGVSASDMAKRHELEQVKTQVLKNLNRFVSRNRLSIHNLPQNY 389
            ....|||||||||||..|.|||:|:|..|:|||...|::|.|.||..|.|||:.||.:||:|::.
Frog   448 PSGIRNLYLAREGLIREGTKAAEGLSPEDLAKRARFEEIKRQKLKCQNIFVSKTRLCVHNIPKSV 512

  Fly   390 DNEKLKQMALTYTG----FRPHECRVMREHKVTPEHPQGKSKGFGFLSFDTHQRALAALRKLNNN 450
            |::||:|:.||.:|    .|..||||||:.|....:.:|:|.|:.|:.|..|:.||||||.:|||
Frog   513 DDKKLRQLFLTASGGGSSVRIKECRVMRDLKGIGGNHKGQSLGYAFVEFLEHEHALAALRSVNNN 577

  Fly   451 PNIFGTQSRPIVAFSIEDRAVHKIKEKRTERS-------------------KQNNPTYQNKQQER 496
            |:|||.:.||||.||:||....|:||||.:||                   .|.||   .|::.|
Frog   578 PDIFGPKKRPIVEFSLEDMNKLKLKEKRAQRSLEVLRQKQAKAQAFGEAVQVQGNP---KKKKLR 639

  Fly   497 KER-----RQQKRNGQETKTPVPQADNKSKLQ------------KHIKKLEASRAAKAEGKVAEK 544
            |:.     .|.....|.:..|..:..||::.:            ...|..|.::.:.|....|.|
Frog   640 KDETSSVPAQHSAGTQASHNPDVKGGNKAEFKTKGNTVDKPTTTSKWKAPEGAQPSSARNNTATK 704

  Fly   545 KQLSDVQGDFVGTAAK-----------------------PGTSLKMRSKKKIVEQAKEHLKKVKT 586
            .:.:.....:.|...|                       .|..::.|.|.|:.:...   ||.||
Frog   705 GKYAKASAPWSGFVTKEEAEQEELPDGKKRKKVLPLPSHKGPKIRARDKGKVHQLPP---KKPKT 766

  Fly   587 EKRKQKNKKIRESHLAERKANNRPKQGRKKETDDLRPLINKYKNMISGNQGGGGVTGGKIKKPKR 651
            :.:..|:|  :::.:.::....:....:.:|......|:.:||..|.|...|....       ||
Frog   767 QPKSHKDK--QQNTITKQVLGKKKLAQKSREEARFSQLVEQYKRKIMGKPVGAAPV-------KR 822

  Fly   652 TKWYTE 657
            :||:.:
Frog   823 SKWFED 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4806	NP_611955.2	RRM	<2..>154	CDD:223796	59/201 (29%)
		RRM_SF	49..124	CDD:302621	33/74 (45%)
		RRM3_RBM28_like	230..306	CDD:240861	28/81 (35%)
		RRM4_RBM28_like	379..468	CDD:240862	45/92 (49%)
rbm28	NP_001123392.1	RRM1_RBM28_like	5..78	CDD:240859	4/15 (27%)
		RRM2_RBM28_like	115..190	CDD:240860	33/74 (45%)
		PABP-1234	126..>631	CDD:130689	186/508 (37%)
		RRM3_RBM28_like	349..431	CDD:240861	28/81 (35%)
		RRM4_RBM28_like	501..595	CDD:240862	45/93 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2353
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1181291at2759
OrthoFinder	1	1.000	-	-		FOG0003903
OrthoInspector	1	1.000	-	-		oto103502
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2687
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160