DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pof and celf4

DIOPT Version :9

Sequence 1:	NP_001246498.1	Gene:	Pof / 37947	FlyBaseID:	FBgn0035047	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_009293466.1	Gene:	celf4 / 436835	ZFINID:	ZDB-GENE-040718-300	Length:	541	Species:	Danio rerio

Alignment Length:	444	Identity:	79/444 - (17%)
Similarity:	141/444 - (31%)	Gaps:	147/444 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LVHLKAGADVEATICDINRVRFGTGHLRAELK----PFSDEEQAEFIDPCSLYVGNIPFNMTTSA 230
            |.:.:..|.|.......|.:..|..|..:...    |..|.      |...|::|.||.|:....
Zfish     4 LTNGQVDAAVHGGAASTNGLVNGISHTHSPASCATIPMKDH------DAIKLFIGQIPRNLDEKD 62

  Fly   231 IKAYFANAMRV-DIGVLKREKRARY---AFVRYASPDQTMEAFKEL--------VDSPLNSRTLT 283
            ::..|....:: ::.|||......:   ||:.|.:.:..::|...|        ::.|:..:...
Zfish    63 LRPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCARESALKAQTALHEQKTLPGMNRPIQVKPAD 127

  Fly   284 VRYRRLRKRAGMPMV---QCATSFQALQSPNGDDDNTDCKVISPPPLESIIISDSDNC------- 338
            ...|...::..:.|:   ||....:.|....|..:  :|.::..|.      .:|..|
Zfish   128 SESRGEDRKLFVGMLNKQQCEDDVRRLFESFGSIE--ECTILRGPD------GNSKGCAFVKYST 184

  Fly   339 --------SDSSGNGKEDGKRKKKI-----NEQEREIEKLKRQMA-----------EYGAIIKSL 379
                    |...|:....|.....:     .::||.|.:: :|||           ::||.....
Zfish   185 HAEAQAAISALHGSQTMPGASSSLVVKFADTDKERTIRRM-QQMAGQMGIFNPMALQFGAYGAYA 248

  Fly   380 QFRQ-------------------------------NSLED--------------------TFIPD 393
            |.:|                               |.|..                    |.||.
Zfish   249 QVQQQAALMASVGQGGYLSPMAAFAAAQMQHMATINGLPGAPMTPTSGGSTPPGITAPTVTSIPS 313

  Fly   394 ------LTPKVEPSVN---PTGCLLGSNAVH-----LMRDIKKECDYLGIPDPVPATKPTTQAQD 444
                  .|....|..|   |...:. :|.:|     .|....:|...|. |..:|..:... .::
Zfish   314 PISVNGFTGLPPPQANGQAPAEAMF-TNGIHPYPVVFMSSATEESKRLS-PGCIPVLQEVV-FRE 375

  Fly   445 DSQK----KAKRSCFGRLFTGPFRRGT---SAMKTADEYEKDDRLEELYAQLER 491
            ||:|    .|:|||||       .:|:   |::..|......|.|::.||.:::
Zfish   376 DSEKGGLGVAQRSCFG-------VQGSCFLSSLSEAQSPTAADPLQQAYAGVQQ 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pof	NP_001246498.1	RRM	<201..>292	CDD:223796	19/106 (18%)
Pof	NP_001246498.1	RRM_SF	217..285	CDD:240668	15/79 (19%)
celf4	XP_009293466.1	RRM1_CELF3_4_5_6	42..128	CDD:241076	17/91 (19%)
		ELAV_HUD_SF	49..537	CDD:273741	70/393 (18%)
		RRM2_CELF3_4_5_6	134..214	CDD:241079	12/87 (14%)
		RRM3_CELF3_4_5_6	452..530	CDD:241083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930