DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pof and CELF3

DIOPT Version :9

Sequence 1:	NP_001246498.1	Gene:	Pof / 37947	FlyBaseID:	FBgn0035047	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_009116.3	Gene:	CELF3 / 11189	HGNCID:	11967	Length:	465	Species:	Homo sapiens

Alignment Length:	323	Identity:	57/323 - (17%)
Similarity:	100/323 - (30%)	Gaps:	119/323 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DPCSLYVGNIPFNMTTSAIKAYFANAMRV-DIGVLKREKRARY---AFVRYASPDQTMEAFKELV 273
            |...|:||.||.::....:|..|....|: ::.|:|.:....:   ||:.|.:.|..::|...|.
Human     5 DAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSALH 69

  Fly   274 DS---PLNSRTLTVRYRRLRKR-------AGM------------------PMVQCATSFQALQSP 310
            :.   |..:|.:.|:......|       .||                  .:.:|.    .|:.|
Human    70 EQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECT----VLRGP 130

  Fly   311 NGDDDNTDCKVIS--------------------PPPLESIIISDSDNCSDSSGNGKEDG-KRKKK 354
            :|  .:..|..:.                    |....|:::..:|       ..||.| :|.::
Human   131 DG--TSKGCAFVKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFAD-------TEKERGLRRMQQ 186

  Fly   355 INEQEREIEKLKRQMAEYGAIIKSLQFRQNSLEDTFIPDLTPKVE---------PSVNPTGCL-- 408
            :..|......:..|...|.|..::|..:|.:|.......|:|...         .::|..|.:
Human   187 VATQLGMFSPIALQFGAYSAYTQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAINANGLIAT 251

  Fly   409 -------------------------LGSNAVHLMRDIKKECDYLGIPDPVPATKPTTQAQDDS 446
                                     ||.|..                .||| |:||.|...|:
Human   252 PITPSSGTSTPPAIAATPVSAIPAALGVNGY----------------SPVP-TQPTGQPAPDA 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pof	NP_001246498.1	RRM	<201..>292	CDD:223796	20/85 (24%)
Pof	NP_001246498.1	RRM_SF	217..285	CDD:240668	18/74 (24%)
CELF3	NP_009116.3	RRM1_CELF3_4_5_6	2..88	CDD:410041	20/82 (24%)
		RRM2_CELF3_4_5_6	94..174	CDD:410043	9/85 (11%)
		PRK12323	<214..>351	CDD:237057	17/101 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..379
		RRM3_CELF3_4_5_6	376..454	CDD:241083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930