DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and Lingo3

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001103079.1	Gene:	Lingo3 / 690755	RGDID:	1592209	Length:	589	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	127/488 - (26%)
Similarity:	170/488 - (34%)	Gaps:	144/488 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LDSVPIFTSDSLHQLNLRHNNISQLVSGNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDL 162
            |.:||.........|.|..|.|..|..|:...|.:|.||.|..|.|..:|.|:|..||.|:||.|
  Rat    44 LTAVPEGIPAETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRL 108

  Fly   163 AHNNLHLLPGHLFAPLLVLGTLDISWNR----------------RFNESGGDL-------YTGLG 204
            ..|.|.|:|..:|..|..|..||:|.|:                |......||       :.||
  Rat   109 RGNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGL- 172

  Fly   205 VNWKLSTLRLDACSLNDL------HLPVNAPLKELSLRRNQLKRIPTQ----LPETLLRLDISDN 259
              ..|:.|.|:.|:|..|      ||   ..|..|.||...:..:..|    || .||.|:| ||
  Rat   173 --LGLAELTLERCNLTSLSPESLGHL---RGLGALRLRHLAIAALEDQNFQKLP-GLLHLEI-DN 230

  Fly   260 --LLEELLPEDT--ANLTQVRQLFIEDMPVLQRVVANSLTHVDVLETLSFQNSRQLSHLDA--EA 318
              ||||:.|...  .|||.:                 |:||.:: ..:.....||.:||..  .:
  Rat   231 WPLLEEVAPGSLRGLNLTSL-----------------SITHTNI-TAVPAAALRQQAHLTCLNLS 277

  Fly   319 FGPIMTTPTKK----------------------------RALRSLSFRGTMLRTFNSTLAPIFTQ 355
            ..||...|...                            |.:|.|:....:|.|...........
  Rat   278 HNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNLLSTLEENTFHSVNT 342

  Fly   356 LAELDLNGLPLQCDCELVWLKQLPVQTN--GR---CYKPARIRG--------------------- 394
            |..|.::|.||.|||.|:|:.|.....|  ||   |..||.:||
  Rat   343 LETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALHNLPDSVLFEYFVCRKPK 407

  Fly   395 ------MLVTSARGD--AFSC--DTWPRWAYGLVVLSLIALSAA---------GIYLIVMGLRPH 440
                  ..||:..||  .|.|  :..|......|.....:::||         |..|.:...||.
  Rat   408 IRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWVTPQHHSVTAASRGRARVLPGGTLAITDTRPQ 472

  Fly   441 RGVT---MRRKVGAGSPY-ARVTIEP--NRQEN 467
            ...|   :....|....| |.:||.|  ||.::
  Rat   473 DSGTYTCVASNAGGNDTYFATLTIHPAANRTQS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	3/9 (33%)
		LRR_8	108..167	CDD:290566	23/58 (40%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR_RI	<121..>261	CDD:238064	55/174 (32%)
		leucine-rich repeat	133..156	CDD:275380	10/22 (45%)
		leucine-rich repeat	157..180	CDD:275380	10/22 (45%)
		leucine-rich repeat	181..208	CDD:275380	10/49 (20%)
		leucine-rich repeat	230..253	CDD:275380	8/26 (31%)
		leucine-rich repeat	254..274	CDD:275380	11/23 (48%)
		leucine-rich repeat	275..299	CDD:275380	3/23 (13%)
		leucine-rich repeat	300..319	CDD:275380	4/20 (20%)
Lingo3	NP_001103079.1	LRRNT	23..55	CDD:214470	3/10 (30%)
		leucine-rich repeat	34..53	CDD:275380	3/8 (38%)
		LRR	<55..353	CDD:227223	85/323 (26%)
		leucine-rich repeat	55..78	CDD:275380	7/22 (32%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		leucine-rich repeat	103..150	CDD:275380	15/46 (33%)
		leucine-rich repeat	151..174	CDD:275380	5/25 (20%)
		leucine-rich repeat	175..198	CDD:275380	8/25 (32%)
		leucine-rich repeat	199..222	CDD:275380	7/23 (30%)
		leucine-rich repeat	223..246	CDD:275380	11/23 (48%)
		LRR_8	246..302	CDD:404697	13/73 (18%)
		leucine-rich repeat	247..270	CDD:275380	7/40 (18%)
		leucine-rich repeat	271..292	CDD:275380	4/20 (20%)
		leucine-rich repeat	295..316	CDD:275380	0/20 (0%)
		leucine-rich repeat	319..342	CDD:275380	4/22 (18%)
		PCC	331..>405	CDD:188093	20/73 (27%)
		Ig	407..489	CDD:416386	16/81 (20%)
		Ig strand A'	413..417	CDD:409353	0/3 (0%)
		Ig strand B	423..432	CDD:409353	2/8 (25%)
		Ig strand C	437..442	CDD:409353	0/4 (0%)
		Ig strand C'	445..447	CDD:409353	0/1 (0%)
		Ig strand D	456..459	CDD:409353	0/2 (0%)
		Ig strand E	462..469	CDD:409353	1/6 (17%)
		Ig strand F	475..483	CDD:409353	1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930