DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4781 and LINGO3

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	414	Identity:	106/414 - (25%)
Similarity:	148/414 - (35%)	Gaps:	126/414 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PWGNRALRIDCSYKDYKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNLRHNNISQLVS 124
            |.|....|.:|:.:...||              .:...|.:||.........|.|..|.|..|..
Human    21 PAGGCPARCECTVQTRAVA--------------CTRRRLTAVPDGIPAETRLLELSRNRIRCLNP 71

  Fly   125 GNFKQLTSLRELYLGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDISWN 189
            |:...|.:|.||.|..|:|..:|.|:|..||.|:||.|..|.|.|:|..:|..|..|..||:|.|
Human    72 GDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSEN 136

  Fly   190 ----------------RRFNESGGDL-------YTGLGVNWKLSTLRLDACSLNDL--------- 222
                            ||......||       :.||   ..|..|.|:.|:|..|
Human   137 KLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL---LALEELTLERCNLTALSGESLGHLR 198

  Fly   223 --------HLPVNAPLKELSLRRNQLKRIPTQLPETLLRLDISDN--LLEELLPEDT--ANLTQV 275
                    ||.:      .||.....:|:|     .||.|:| ||  ||||:.....  .|||.:
Human   199 SLGALRLRHLAI------ASLEDQNFRRLP-----GLLHLEI-DNWPLLEEVAAGSLRGLNLTSL 251

  Fly   276 RQLFIEDMPVLQRVVANSLTHVDV--LETLSFQNSRQLSHLDAEAFGPIMTTPTKK--------- 329
                             |:||.::  :...:.::...|:.|:. :..||.|.|...
Human   252 -----------------SVTHTNITAVPAAALRHQAHLTCLNL-SHNPISTVPRGSFRDLVRLRE 298

  Fly   330 -------------------RALRSLSFRGTMLRTFNSTLAPIFTQLAELDLNGLPLQCDCELVWL 375
                               |.:|.|:....:|.|...:.......|..|.::|.||.|||.|:|:
Human   299 LHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWI 363

  Fly   376 KQLPVQTN--GR---CYKPARIRG 394
            .|.....|  ||   |..||.:||
Human   364 VQRRKTLNFDGRLPACATPAEVRG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	3/17 (18%)
		LRR_8	108..167	CDD:290566	23/58 (40%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		LRR_RI	<121..>261	CDD:238064	53/181 (29%)
		leucine-rich repeat	133..156	CDD:275380	10/22 (45%)
		leucine-rich repeat	157..180	CDD:275380	10/22 (45%)
		leucine-rich repeat	181..208	CDD:275380	11/49 (22%)
		leucine-rich repeat	230..253	CDD:275380	5/22 (23%)
		leucine-rich repeat	254..274	CDD:275380	10/23 (43%)
		leucine-rich repeat	275..299	CDD:275380	3/23 (13%)
		leucine-rich repeat	300..319	CDD:275380	2/18 (11%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	7/47 (15%)
		LRR 1	55..76		6/20 (30%)
		LRR_8	57..138	CDD:290566	33/80 (41%)
		LRR_4	59..95	CDD:289563	13/35 (37%)
		leucine-rich repeat	59..79	CDD:275380	7/19 (37%)
		LRR 2	79..100		9/20 (45%)
		leucine-rich repeat	80..103	CDD:275380	10/22 (45%)
		LRR 3	103..124		9/20 (45%)
		leucine-rich repeat	104..127	CDD:275380	10/22 (45%)
		LRR_RI	111..>286	CDD:238064	50/207 (24%)
		LRR_8	127..>172	CDD:290566	9/44 (20%)
		LRR 4	127..148		5/20 (25%)
		leucine-rich repeat	128..151	CDD:275380	5/22 (23%)
		LRR 5	151..172		4/20 (20%)
		leucine-rich repeat	152..199	CDD:275380	12/49 (24%)
		LRR 6	175..196		6/20 (30%)
		LRR_8	198..258	CDD:290566	22/88 (25%)
		leucine-rich repeat	200..223	CDD:275380	6/33 (18%)
		LRR 7	207..228		8/31 (26%)
		leucine-rich repeat	224..247	CDD:275380	10/23 (43%)
		LRR_8	247..303	CDD:290566	12/73 (16%)
		LRR 8	247..268		6/37 (16%)
		leucine-rich repeat	248..271	CDD:275380	5/39 (13%)
		LRR 9	271..292		6/21 (29%)
		leucine-rich repeat	272..293	CDD:275380	6/21 (29%)
		LRR 10	295..316		0/20 (0%)
		leucine-rich repeat	296..319	CDD:275380	0/22 (0%)
		LRR 11	319..340		4/20 (20%)
		leucine-rich repeat	322..343	CDD:275380	3/20 (15%)
		I-set	407..497	CDD:254352
		Ig	422..490	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930