DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4781 and LRRC4

DIOPT Version :9

Sequence 1:	NP_611951.1	Gene:	CG4781 / 37943	FlyBaseID:	FBgn0035043	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	439	Identity:	104/439 - (23%)
Similarity:	155/439 - (35%)	Gaps:	148/439 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTFALLLTQ--LLAAHVARAEVIDAEETDRFCYPESSKNSRRSCECSNVSASPWGNRALRIDCSY 72
            |.|..|..|  :|.|.:|.|.            ....:|....|.||        |:..::.|:.
Human    19 LPFVYLTAQVWILCAAIAAAA------------SAGPQNCPSVCSCS--------NQFSKVVCTR 63

  Fly    73 KDYKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNLRHNNISQLVSGNFKQLTSLRELY 137
            :                       .|..||.....:...|||..|||..:.:..|:.|..|..|.
Human    64 R-----------------------GLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105

  Fly   138 LGWNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDISWNRRFNESGGDLYTG 202
            ||.|||.::|.|:|:||..|..|:|..|.|.::|...|..|
Human   106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYL------------------------ 146

  Fly   203 LGVNWKLSTLRLDACSLNDLHLPVNAPLKELSLRRNQLKRIPT----QLPETLLRLD-------- 255
                                     :.|:||.||.|.::.||:    ::| :|:|||
Human   147 -------------------------SKLRELWLRNNPIESIPSYAFNRVP-SLMRLDLGELKKLE 185

  Fly   256 -ISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVA----------------NSLTHVDVLETL 303
             ||:...|.|......||....   |:|||.|..:|.                .|...:..|:.|
Human   186 YISEGAFEGLFNLKYLNLGMCN---IKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKL 247

  Fly   304 SFQNSRQLSHLDAEAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAPIFT---QLAELDLNGLP 365
            ...|| |:|.::..||..:.:......|..:||          |....:||   .|.||.|:..|
Human   248 WVMNS-QVSLIERNAFDGLASLVELNLAHNNLS----------SLPHDLFTPLRYLVELHLHHNP 301

  Fly   366 LQCDCELVWL-----KQLPVQTN--GRCYKPARIRGMLVTSARGDAFSC 407
            ..|||:::||     :.:|..:.  |||:.|..:||..:......:|.|
Human   302 WNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQC 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4781	NP_611951.1	leucine-rich repeat	90..108	CDD:275380	3/17 (18%)
		LRR_8	108..167	CDD:290566	24/58 (41%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR_RI	<121..>261	CDD:238064	37/152 (24%)
		leucine-rich repeat	133..156	CDD:275380	12/22 (55%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..208	CDD:275380	0/26 (0%)
		leucine-rich repeat	230..253	CDD:275380	10/26 (38%)
		leucine-rich repeat	254..274	CDD:275380	8/28 (29%)
		leucine-rich repeat	275..299	CDD:275380	7/39 (18%)
		leucine-rich repeat	300..319	CDD:275380	6/18 (33%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	8/63 (13%)
		LRR	<74..291	CDD:227223	68/280 (24%)
		LRR 1	76..97		7/20 (35%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR 2	100..121		10/20 (50%)
		leucine-rich repeat	101..124	CDD:275380	12/22 (55%)
		LRR 3	124..145		7/20 (35%)
		leucine-rich repeat	125..148	CDD:275380	8/71 (11%)
		LRR 4	148..169		8/20 (40%)
		leucine-rich repeat	149..172	CDD:275380	9/23 (39%)
		LRR 5	172..194		6/21 (29%)
		leucine-rich repeat	173..197	CDD:275380	8/23 (35%)
		LRR 6	197..218		7/23 (30%)
		leucine-rich repeat	198..219	CDD:275380	7/23 (30%)
		LRR 7	219..240		1/20 (5%)
		leucine-rich repeat	220..243	CDD:275380	1/22 (5%)
		LRR 8	243..264		8/21 (38%)
		leucine-rich repeat	244..267	CDD:275380	8/23 (35%)
		LRR 9	267..288		5/30 (17%)
		leucine-rich repeat	268..289	CDD:275380	6/30 (20%)
		LRRCT	300..351	CDD:214507	15/51 (29%)
		IG	359..441	CDD:214652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910