DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4781 and LRRC4C

DIOPT Version :9

Sequence 1:NP_611951.1 Gene:CG4781 / 37943 FlyBaseID:FBgn0035043 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001245348.1 Gene:LRRC4C / 57689 HGNCID:29317 Length:640 Species:Homo sapiens


Alignment Length:428 Identity:101/428 - (23%)
Similarity:153/428 - (35%) Gaps:133/428 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LTFALLLTQLLAAHVARAEVIDAEETDRFCYPESSKNSRRSCECSNVSASPWGNRALRIDCSYKD 74
            |...|.|..|:.|.:.||:...:                 .|.||        |:..::.|..|:
Human    27 LVVLLALQLLVVAGLVRAQTCPS-----------------VCSCS--------NQFSKVICVRKN 66

  Fly    75 YKVADLSLLLPLYIDSLDLSWNALDSVPIFTSDSLHQLNLRHNNISQLVSGNFKQLTSLRELYLG 139
                                   |..||...|.:...|||..|.|..:...:||.|..|..|.|.
Human    67 -----------------------LREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLS 108

  Fly   140 WNSIGKLESGSFDGLPHLQVLDLAHNNLHLLPGHLFAPLLVLGTLDISWNRR----------FNE 194
            .|.|..:|.|:|:||.:|..|:|..|.|..:|...|..|..|..|   |.|.          || 
Human   109 RNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKEL---WLRNNPIESIPSYAFN- 169

  Fly   195 SGGDLYTGLGVNWKLSTL-RLDACSLNDL-HLPVNA-----PLKELSLRRNQLKRIPTQLPETLL 252
                         ::.:| |||...|..| ::...|     .|:.|:|....|:.||...|...|
Human   170 -------------RIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKL 221

  Fly   253 -RLDISDNLLEELLPEDTANLTQVRQLFIEDMPVLQRVVANSLTHVDVLETLSFQNSRQLSHLDA 316
             .||:|.|.|..:.|.....|..:::|:     ::|       :.:.|:|..:|.|.:.|..:: 
Human   222 DELDLSGNHLSAIRPGSFQGLMHLQKLW-----MIQ-------SQIQVIERNAFDNLQSLVEIN- 273

  Fly   317 EAFGPIMTTPTKKRALRSLSFRGTMLRTFNSTLAP--IFTQLAELD---LNGLPLQCDCELVWLK 376
                                     |...|.||.|  :||.|..|:   |:..|..|:|:::||.
Human   274 -------------------------LAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS 313

  Fly   377 -----QLPVQTN--GRCYKPARIRGMLVTSARGDAFSC 407
                 ..|..|.  .||..|..::|..:.....:.|:|
Human   314 WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4781NP_611951.1 leucine-rich repeat 90..108 CDD:275380 4/17 (24%)
LRR_8 108..167 CDD:290566 22/58 (38%)
leucine-rich repeat 109..132 CDD:275380 8/22 (36%)
LRR_RI <121..>261 CDD:238064 46/157 (29%)
leucine-rich repeat 133..156 CDD:275380 10/22 (45%)
leucine-rich repeat 157..180 CDD:275380 8/22 (36%)
leucine-rich repeat 181..208 CDD:275380 6/36 (17%)
leucine-rich repeat 230..253 CDD:275380 8/23 (35%)
leucine-rich repeat 254..274 CDD:275380 7/19 (37%)
leucine-rich repeat 275..299 CDD:275380 2/23 (9%)
leucine-rich repeat 300..319 CDD:275380 4/18 (22%)
LRRC4CNP_001245348.1 LRRNT 47..80 CDD:214470 10/80 (13%)
PPP1R42 65..235 CDD:411060 57/209 (27%)
LRR 1 77..98 6/20 (30%)
leucine-rich repeat 78..101 CDD:275380 8/22 (36%)
LRR 2 101..122 8/20 (40%)
leucine-rich repeat 102..125 CDD:275380 10/22 (45%)
LRR 3 125..146 7/20 (35%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
LRR 4 149..170 6/37 (16%)
leucine-rich repeat 150..173 CDD:275380 6/39 (15%)
LRR 5 173..195 7/21 (33%)
leucine-rich repeat 174..198 CDD:275380 7/23 (30%)
LRR 6 198..219 7/20 (35%)
leucine-rich repeat 199..220 CDD:275380 7/20 (35%)
LRR_8 220..279 CDD:404697 16/96 (17%)
LRR 7 220..241 7/20 (35%)
leucine-rich repeat 221..244 CDD:275380 8/22 (36%)
LRR 8 244..265 5/32 (16%)
leucine-rich repeat 245..268 CDD:275380 6/34 (18%)
LRR_8 267..>301 CDD:404697 11/59 (19%)
LRR 9 268..289 7/46 (15%)
leucine-rich repeat 269..290 CDD:275380 8/46 (17%)
LRRCT 301..>339 CDD:214507 10/37 (27%)
IG 360..443 CDD:214652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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